Document Detail


High-frequency oscillatory ventilation increases canine pulmonary epithelial permeability.
MedLine Citation:
PMID:  2826384     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To investigate the effect of high-frequency oscillatory ventilation (HFOV) on the pulmonary epithelial permeability, we measured the clearance rate of nebulized sodium pertechnetate (99mTcO4-) and diethylenetriaminepentaacetate (99mTc-DTPA) before and after a 4-h period of mechanical ventilation in anesthetized mongrel dogs. The animals also underwent experiments with 4 h of spontaneous breathing (SB) and intermittent positive-pressure ventilation (IPPV) with and without addition of positive end-expiratory pressure (PEEP) for comparison. After IPPV and SB there was no change in the clearance rate of either 99mTcO4- or 99mTc-DTPA. After IPPV + PEEP and HPOV (8 and 16 Hz), there was an increase in the clearance rate of 99mTc-DTPA, but an increase in clearance rate of 99mTcO4- was seen after IPPV + PEEP only. In a separate group of dogs an increase in end-tidal lung volume was demonstrated after 4 h of ventilation with IPPV + PEEP (but not after HFOV), and this may account for the measured increase in 99mTcO4- clearance. We conclude that an increase in 99mTc-DTPA clearance rate after HFOV signifies an increase in pulmonary epithelial permeability, possibly through the mechanism of damage to the intercellular junctions during HFOV.
Authors:
G C Man; I H Ahmed; J W Logus; S F Man
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  63     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1987 Nov 
Date Detail:
Created Date:  1988-01-27     Completed Date:  1988-01-27     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1871-6     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of Alberta, Edmonton, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Carbon Dioxide / blood
Cell Membrane Permeability*
Dogs
Epithelium / metabolism
High-Frequency Ventilation*
Lung / metabolism*
Lung Volume Measurements
Mucociliary Clearance
Organometallic Compounds / diagnostic use
Oxygen / blood
Pentetic Acid / diagnostic use
Positive-Pressure Respiration
Sodium Pertechnetate Tc 99m / diagnostic use
Technetium Tc 99m Pentetate
Chemical
Reg. No./Substance:
0/Organometallic Compounds; 124-38-9/Carbon Dioxide; 23288-60-0/Sodium Pertechnetate Tc 99m; 65454-61-7/Technetium Tc 99m Pentetate; 67-43-6/Pentetic Acid; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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