Document Detail

High-frequency oscillatory ventilation in children with acute respiratory distress syndrome: Experience of a pediatric intensive care unit.
MedLine Citation:
PMID:  23849709     Owner:  NLM     Status:  Publisher    
OBJECTIVE: To describe the effects of high-frequency oscillatory ventilation (HFOV) as a rescue ventilatory support in pediatric patients with acute respiratory distress syndrome (ARDS).
METHODS: Twenty-five children (1 month < age < 17 years) admitted to a university hospital pediatric intensive care unit (ICU) with ARDS and submitted to HFOV for a minimum of 48hours after failure of conventional mechanical ventilation were assessed.
RESULTS: Twenty eight days after the onset of ARDS, the mortality rate was 52% (13/25). Over the course of 48hours, the use of HFOV reduced the oxygenation index [38 (31-50) vs. 17 (10-27)] and increased the ratio of partial arterial pressure O2 and fraction of inspired O2 [65 [44-80) vs. 152 (106-213)]. Arterial CO2 partial pressure [54 (45-74) vs. 48 (39-58) mmHg] remained unchanged. The mean airway pressure ranged between 23 and 29 cmH2O. HFOV did not compromise hemodynamics, and a reduction in heart rate was observed (141±32 vs. 119 beats/min), whereas mean arterial pressure (66±20 vs. 71±17mmHg) and inotropic score [44 (17-130) vs. 20 (16-75)] remained stable during this period. No survivors were dependent on oxygen.
CONCLUSION: HFOV improves oxygenation in pediatric patients with ARDS and severe hypoxemia refractory to conventional ventilatory support.
Anelise Dentzien Pinzon; Taís Sica da Rocha; Cláudia Ricachinevsky; Jefferson Pedro Piva; Gilberto Friedman
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-7-10
Journal Detail:
Title:  Revista da Associacao Medica Brasileira (1992)     Volume:  -     ISSN:  0104-4230     ISO Abbreviation:  Rev Assoc Med Bras     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-7-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9308586     Medline TA:  Rev Assoc Med Bras     Country:  -    
Other Details:
Languages:  ENG; POR     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Elsevier Editora Ltda. All rights reserved.
UTI Pediátrica, Hospital de Criança Santo Antônio, Complexo Hospitalar Santa Casa, Porto Alegre, RS, Brasil; Programa de Pós-graduação em Ciências Pneumológicas, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brasil.
Vernacular Title:
Ventilação oscilatória de alta frequência em crianças com síndrome da angústia respiratória aguda: experiência de um centro de tratamento intensivo pediátrico.
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