Document Detail

High-frequency oscillatory ventilation attenuates oxidative lung injury in a rabbit model of acute lung injury.
MedLine Citation:
PMID:  21930717     Owner:  NLM     Status:  MEDLINE    
Mechanical ventilation (MV) can induce lung oxidative stress, which plays an important role in pulmonary injury. This study compared protective conventional mechanical ventilation (CMV) and high-frequency oscillatory ventilation (HFOV) for oxygenation, oxidative stress, inflammatory and histopathological lung injury in a rabbit model of acute lung injury (ALI). Rabbits (n = 30) were ventilated at FiO(2) 1.0. Lung injury was induced by tracheal saline infusion (30 mL/kg, 38°C). Animals were randomly assigned to: (a) sham control (CG: tidal volume [V(T)] 6 mL/kg, positive end expiratory pressure [PEEP] 5 cmH(2)O, respiratory rate [RR] 40 ipm); (b) ALI + CMV (CMVG: V(T) 6 mL/kg, PEEP 10 cmH(2)O, RR 40 ipm); or (c) ALI + HFOV (HFG: mean airway pressure [Paw] 14 cmH(2)O, RR 10 Hz) groups. Lung oxidative stress was assessed by total antioxidant performance assay, inflammatory response by the number of polymorphonuclear leukocytes/bronchoalveolar lavage fluid/lung and pulmonary histological damage was quantified by a score. Ventilatory and hemodynamic parameters were recorded every 30 min. Both ALI groups showed worse oxygenation after lung injury induction. After four hours of ventilation, HFG showed better oxygenation (partial pressure of oxygen [PaO(2)] - CG: 465.9 ± 30.5 = HFG: 399.1 ± 98.2 > CMVG: 232.7 ± 104 mmHg, P < 0.05) and inflammatory responses (CMVG: 4.27 ± 1.50 > HFG: 0.33 ± 0.20 = CG: 0.16 ± 0.15; polymorphonuclear cells/bronchoalveolar lavage fluid/lung, P < 0.05), less histopathological injury score (CMVG: 5 [1-16] > HFG: 1 [0-5] > CG: 0 [0-3]; P < 0.05), and lower lung oxidative stress than CMVG (CG: 59.4 ± 4.52 = HFG: 69.0 ± 4.99 > CMVG: 47.6 ± 2.58% protection/g protein, P < 0.05). This study showed that HFOV had an important protective role in ALI. It improved oxygenation, reduced inflammatory process and histopathological damage, and attenuated oxidative lung injury compared with protective CMV under these experimental conditions considering the study limitations.
Carlos Fernando Ronchi; Ana Lucia dos Anjos Ferreira; Fabio Joly Campos; Cilmery Suemi Kurokawa; Mario Ferreira Carpi; Marcos Aurelio de Moraes; Rossano Cesar Bonatto; Julio Defaveri; Kyung-Jin Yeum; Jose Roberto Fioretto
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2011-09-19
Journal Detail:
Title:  Experimental biology and medicine (Maywood, N.J.)     Volume:  236     ISSN:  1535-3699     ISO Abbreviation:  Exp. Biol. Med. (Maywood)     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-03     Completed Date:  2011-11-29     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  100973463     Medline TA:  Exp Biol Med (Maywood)     Country:  England    
Other Details:
Languages:  eng     Pagination:  1188-96     Citation Subset:  IM    
Internal Medicine Department, Sao Paulo State University, Botucatu Medical School, 18618-970 Botucatu, SP, Brazil.
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MeSH Terms
Acute Lung Injury / pathology,  physiopathology,  therapy*
Bronchoalveolar Lavage Fluid / cytology
Disease Models, Animal
Hemodynamics / physiology
High-Frequency Ventilation*
Inflammation / therapy
Lung / pathology,  physiopathology
Lung Compliance / physiology
Neutrophils / physiology
Oxidative Stress / physiology
Pulmonary Gas Exchange
Respiration, Artificial

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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