| High-frequency oscillations mirror disease activity in patients with epilepsy. | |
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MedLine Citation:
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PMID: 19289737 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: High-frequency oscillations (HFOs) can be recorded in epileptic patients with clinical intracranial EEG. HFOs have been associated with seizure genesis because they occur in the seizure focus and during seizure onset. HFOs are also found interictally, partly co-occurring with epileptic spikes. We studied how HFOs are influenced by antiepileptic medication and seizure occurrence, to improve understanding of the pathophysiology and clinical meaning of HFOs. METHODS: Intracerebral depth EEG was partly sampled at 2,000 Hz in 42 patients with intractable focal epilepsy. Patients with five or more usable nights of recording were selected. A sample of slow-wave sleep from each night was analyzed, and HFOs (ripples: 80-250 Hz, fast ripples: 250-500 Hz) and spikes were identified on all artifact-free channels. The HFOs and spikes were compared before and after seizures with stable medication dose and during medication reduction with no intervening seizures. RESULTS: Twelve patients with five to eight nights were included. After seizures, there was an increase in spikes, whereas HFO rates remained the same. Medication reduction was followed by an increase in HFO rates and mean duration. CONCLUSIONS: Contrary to spikes, high-frequency oscillations (HFOs) do not increase after seizures, but do so after medication reduction, similarly to seizures. This implies that spikes and HFOs have different pathophysiologic mechanisms and that HFOs are more tightly linked to seizures than spikes. HFOs seem to play an important role in seizure genesis and can be a useful clinical marker for disease activity. |
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Authors:
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M Zijlmans; J Jacobs; R Zelmann; F Dubeau; J Gotman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neurology Volume: 72 ISSN: 1526-632X ISO Abbreviation: Neurology Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-03-17 Completed Date: 2009-04-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401060 Medline TA: Neurology Country: United States |
Other Details:
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Languages: eng Pagination: 979-86 Citation Subset: AIM; IM |
Affiliation:
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Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anticonvulsants / therapeutic use* Electrocardiography Electroencephalography* Electromyography Epilepsy / drug therapy*, physiopathology* Female Humans Male Middle Aged Polysomnography Seizures / physiopathology Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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