Document Detail


High-frequency oscillations, extent of surgical resection, and surgical outcome in drug-resistant focal epilepsy.
MedLine Citation:
PMID:  23294353     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Removal of areas generating high-frequency oscillations (HFOs) recorded from the intracerebral electroencephalography (iEEG) of patients with medically intractable epilepsy has been found to be correlated with improved surgical outcome. However, whether differences exist according to the type of epilepsy is largely unknown. We performed a comparative assessment of the impact of removing HFO-generating tissue on surgical outcome between temporal lobe epilepsy (TLE) and extratemporal lobe epilepsy (ETLE). We also assessed the relationship between the extent of surgical resection and surgical outcome.
METHODS: We studied 30 patients with drug-resistant focal epilepsy, 21 with TLE and 9 with ETLE. Two thirds of the patients were included in a previous report and for these, clinical and imaging data were updated and follow-up was extended. All patients underwent iEEG investigations (500 Hz high-pass filter and 2,000 Hz sampling rate), surgical resection, and postoperative magnetic resonance imaging (MRI). HFOs (ripples, 80-250 Hz; fast ripples, >250 Hz) were identified visually on a 5-10 min interictal iEEG sample. HFO rates inside versus outside the seizure-onset zone (SOZ), in resected versus nonresected tissue, and their association with surgical outcome (ILAE classification) were assessed in the entire cohort, and in the TLE and ETLE subgroups. We also tested the correlation of resected brain hippocampal and amygdala volumes (as measured on postoperative MRIs) with surgical outcome.
KEY FINDINGS: HFO rates were significantly higher inside the SOZ than outside in the entire cohort and TLE subgroup, but not in the ETLE subgroup. In all groups, HFO rates did not differ significantly between resected and nonresected tissue. Surgical outcome was better when higher HFO rates were included in the surgical resection in the entire cohort and TLE subgroup, but not in the ETLE subgroup. Resected brain hippocampal and amygdala volumes were not correlated with surgical outcome.
SIGNIFICANCE: In TLE, removal of HFO-generating areas may lead to improved surgical outcome. Less consistent findings emerge from ETLE, but these may be related to sample size limitations of this study. Size of resection, a factor that was ignored and that could have affected results of earlier studies did not influence results.
Authors:
Claire Haegelen; Piero Perucca; Claude-Edouard Châtillon; Luciana Andrade-Valença; Rina Zelmann; Julia Jacobs; D Louis Collins; François Dubeau; André Olivier; Jean Gotman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-01-07
Journal Detail:
Title:  Epilepsia     Volume:  54     ISSN:  1528-1167     ISO Abbreviation:  Epilepsia     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-29     Completed Date:  2013-06-25     Revised Date:  2013-07-19    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  United States    
Other Details:
Languages:  eng     Pagination:  848-57     Citation Subset:  IM    
Copyright Information:
Wiley Periodicals, Inc. © 2012 International League Against Epilepsy.
Affiliation:
EEG Department, Montreal Neurological Institute, Montreal, Quebec, Canada.
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MeSH Terms
Descriptor/Qualifier:
Adult
Biological Clocks / physiology*
Brain Mapping*
Brain Waves / physiology*
Electroencephalography
Epilepsy, Temporal Lobe / physiopathology*,  surgery*
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Treatment Outcome
Young Adult
Grant Support
ID/Acronym/Agency:
102710-1//Canadian Institutes of Health Research; MOP 102710//Canadian Institutes of Health Research
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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