Document Detail

High-frequency oscillation affects surfactant phospholipid metabolism in rabbits.
MedLine Citation:
PMID:  6393262     Owner:  NLM     Status:  MEDLINE    
Surfactant phospholipid metabolism was studied in anesthetized rabbits ventilated with high-frequency oscillation at a frequency of 5 Hz and a mean airway pressure of 5 cm H2O. Blood gases were normal although some atelectasis was evident after 1 h. The static compliance of the lungs and amount and composition of surfactant phospholipids of the lamellar body and alveolar lavage fraction were comparable to values found for spontaneously breathing rabbits. The data obtained for the incorporation of radioactively labeled palmitate into phospholipids are compatible with intracellular degradation of newly synthesized surfactant phospholipids. This hypothesis is supported by two observations. First, the rapid initial increase in specific activity of SPC and PC of the lamellar body fraction is not accompanied by a similar rapid increase in specific activity of SPC and PC of the lamellar body fraction is not accompanied by a similar rapid increase in specific activity of the alveolar lavage fraction. Second, a dissociation occurs between the metabolism of PC and SPC for the lamellar body fraction but not for the alveolar lavage fraction. The change in metabolism might be caused by the absence of large pressure swings during this pattern of ventilation.
J J Ennema; D J Reijngoud; J Egberts; P H Mook; C R Wildevuur
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Respiration physiology     Volume:  58     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  1984 Oct 
Date Detail:
Created Date:  1985-02-14     Completed Date:  1985-02-14     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  29-39     Citation Subset:  IM    
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MeSH Terms
Blood Gas Analysis
Lung / physiology
Lung Compliance
Palmitates / metabolism
Phospholipids / metabolism*
Positive-Pressure Respiration
Pulmonary Alveoli / physiology
Pulmonary Surfactants / metabolism*
Radio Waves
Respiration, Artificial / methods*
Reg. No./Substance:
0/Palmitates; 0/Phospholipids; 0/Pulmonary Surfactants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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