Document Detail

High-frequency jet ventilation versus conventional ventilation after surfactant displacement in dogs.
MedLine Citation:
PMID:  6205822     Owner:  NLM     Status:  MEDLINE    
High-frequency jet ventilation (HFJV) was compared with conventional ventilation (CV) after surfactant displacement with diocytyl sodium sulfosuccinate (OT) via ultrasonic nebulization. After aerosol delivery, dogs were separated into 3 groups and followed for 2 h. Ventilator settings were not changed in group I (CV) and group II (HFJV) after OT delivery. In group III, drive pressure was increased to 40 psi. Adequacy of oxygenation varied directly with peak inspiratory pressure (PIP) rather than airway pressure (Paw) in both HFJV and CV. In all groups, immediately after OT administration PaO2 decreased and there was a slight increase in Paw; PIP was significantly elevated only in groups I and III. Two hours later, PaO2 had returned to baseline in groups I and III, but had not improved significantly in group II. Paw remained the same in all groups. These data demonstrate that in noncompliant lungs, oxygenation is not improved unless a high PIP is used to establish the critical opening pressures needed to rerecruit alveoli. In this noncompliant lung model, HFJV was not effective at low Paw values, and thus offered no apparent advantage over CV.
B S Kumar; K Beney; M Jastremski; G Nieman; C Bredenberg
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Critical care medicine     Volume:  12     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  1984 Sep 
Date Detail:
Created Date:  1984-10-25     Completed Date:  1984-10-25     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  738-41     Citation Subset:  AIM; IM    
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MeSH Terms
Dioctyl Sulfosuccinic Acid / pharmacology
Disease Models, Animal
Lung Compliance* / drug effects
Pulmonary Atelectasis / physiopathology
Pulmonary Gas Exchange
Pulmonary Surfactants
Respiration, Artificial / methods*
Surface-Active Agents / pharmacology
Reg. No./Substance:
0/Pulmonary Surfactants; 0/Surface-Active Agents; 10041-19-7/Dioctyl Sulfosuccinic Acid
Erratum In:
Crit Care Med. 2003 Apr;28(2):368

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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