| High-frequency jet ventilation and surfactant treatment of newborns with severe respiratory failure. | |
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MedLine Citation:
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PMID: 1495854 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Twenty-eight newborn infants (birthweight, 2.4 +/- 1.1 kg; gestational age, 34.6 +/- 6.1 weeks) with respiratory distress syndrome (RDS), meconium aspiration syndrome, or pneumonia who deteriorated in spite of optimal conventional mechanical ventilation (CMV) and exogenous surfactant therapy were treated with high-frequency jet ventilation (HFJV) and continued surfactant therapy. For enrollment, infants had to have a limited response to surfactant therapy and conventional ventilation, and meet clinical criteria that confirmed clinical deterioration and severity of illness. Study infants had received exogenous calf lung surfactant extract (CLSE) and conventional ventilation prior to the start of HFJV at 46.3 +/- 8.2 hours of age. Patients initially responded to HFJV alone with significant improvement in several respiratory variables, but deteriorated subsequently and receive additional doses of exogenous surfactant on HFJV. Exogenous surfactant and HFJV resulted in significant and sustained improvement in several respiratory variables. Only ten patients deteriorated to meet criteria for a second surfactant dose on HFJV, and two patients received a third dose. Twenty-five of the 28 patients studied survived (89%). No patients received extracorporeal membrane oxygenation or were discharged home on oxygen. The results of this pilot study suggest that the combination of HFJV and exogenous surfactant replacement may be effective in treating infants with more severe respiratory failure, and indicate the need for more extensive controlled investigations. |
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Authors:
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J M Davis; S E Richter; J W Kendig; R H Notter |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Pediatric pulmonology Volume: 13 ISSN: 8755-6863 ISO Abbreviation: Pediatr. Pulmonol. Publication Date: 1992 Jun |
Date Detail:
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Created Date: 1992-09-10 Completed Date: 1992-09-10 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8510590 Medline TA: Pediatr Pulmonol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 108-12 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Winthrop-University Hospital, State University of New York, Stony Brook School of Medicine, Mineola. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Gestational Age High-Frequency Jet Ventilation* Humans Infant, Newborn Meconium Aspiration Syndrome / therapy Pneumonia / therapy Pulmonary Surfactants / therapeutic use* Respiratory Distress Syndrome, Newborn / therapy Respiratory Insufficiency / therapy* |
| Grant Support | |
ID/Acronym/Agency:
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HL-36543/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Pulmonary Surfactants |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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