Document Detail


High frequency of endothelial colony forming cells marks a non-active myeloproliferative neoplasm with high risk of splanchnic vein thrombosis.
MedLine Citation:
PMID:  21151606     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Increased mobilization of circulating endothelial progenitor cells may represent a new biological hallmark of myeloproliferative neoplasms. We measured circulating endothelial colony forming cells (ECFCs) in 106 patients with primary myelofibrosis, fibrotic stage, 49 with prefibrotic myelofibrosis, 59 with essential thrombocythemia or polycythemia vera, and 43 normal controls. Levels of ECFC frequency for patient's characteristics were estimated by using logistic regression in univariate and multivariate setting. The sensitivity, specificity, likelihood ratios, and positive predictive value of increased ECFC frequency were calculated for the significantly associated characteristics. Increased frequency of ECFCs resulted independently associated with history of splanchnic vein thrombosis (adjusted odds ratio = 6.61, 95% CI = 2.54-17.16), and a summary measure of non-active disease, i.e. hemoglobin of 13.8 g/dL or lower, white blood cells count of 7.8×10(9)/L or lower, and platelet count of 400×10(9)/L or lower (adjusted odds ratio = 4.43, 95% CI = 1.45-13.49) Thirteen patients with splanchnic vein thrombosis non associated with myeloproliferative neoplasms were recruited as controls. We excluded a causal role of splanchnic vein thrombosis in ECFCs increase, since no control had elevated ECFCs. We concluded that increased frequency of ECFCs represents the biological hallmark of a non-active myeloproliferative neoplasm with high risk of splanchnic vein thrombosis. The recognition of this disease category copes with the phenotypic mimicry of myeloproliferative neoplasms. Due to inherent performance limitations of ECFCs assay, there is an urgent need to arrive to an acceptable standardization of ECFC assessment.
Authors:
Vittorio Rosti; Elisa Bonetti; Gaetano Bergamaschi; Rita Campanelli; Paola Guglielmelli; Marcello Maestri; Umberto Magrini; Margherita Massa; Carmine Tinelli; Gianluca Viarengo; Laura Villani; Massimo Primignani; Alessandro M Vannucchi; Francesco Frassoni; Giovanni Barosi;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-12-09
Journal Detail:
Title:  PloS one     Volume:  5     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2010  
Date Detail:
Created Date:  2010-12-14     Completed Date:  2011-07-05     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e15277     Citation Subset:  IM    
Affiliation:
Unit of Clinical Epidemiology and Center for the Study of Myelofibrosis, IRCCS Policlinico S. Matteo Foundation, Pavia, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Cohort Studies
Cross-Sectional Studies
Endothelial Cells / cytology*
Female
Hemoglobins / metabolism
Humans
Likelihood Functions
Male
Middle Aged
Myeloproliferative Disorders / complications*,  pathology*
Odds Ratio
Polycythemia Vera / pathology
Sensitivity and Specificity
Splanchnic Circulation*
Thrombocytopenia / pathology
Venous Thrombosis / pathology*
Chemical
Reg. No./Substance:
0/Hemoglobins
Investigator
Investigator/Affiliation:
Alessandro Maria Vannucchi / ; Elisabetta Antonioli / ; Niccolò Bartalucci / ; Flavia Biamonte / ; Costanza Bogani / ; Alberto Bosi / ; Rajmonda Fjerza / ; Paola Guglielmelli / ; Elisa Malevolti / ; Alessandro Pancrazzi / ; Lisa Pieri / ; Ambra Spolverini / ; Maria Chiara Susini / ; Lorenzo Tozzi / ; Stefania Bortoluzzi / ; Andrea Bisognin / ; Alessandro Coppe / ; Roberto Marchioli / ; Giovanni Barosi / ; Cristina Azzan / ; Stefania Badalucco / ; Alessandra Balduini / ; Gaetano Bergamaschi / ; Elisa Bonetti / ; Rita Campanelli / ; Adriana Carolei / ; Manuela Currao / ; Maria Antonina Isgrò / ; Maria Letizia Lupo / ; Umberto Magrini / ; Margherita Massa / ; Viviana Magni / ; Vittorio Rosti / ; Laura Villani / ; Mario Cazzola / ; Paolo Bernasconi / ; Sabrina Boggi / ; Chiara Elena / ; Anna Gallì / ; Luca Malcovati / ; Cristiana Pascutto / ; Francesco Passamonti / ; Daniela Pietra / ; Elisa Rumi / ; Elisabetta Dejana / ; Monica Corada / ; Monica Giannotta / ; Alessandro Rambaldi / ; Maria Luisa Ferrari / ; Guido Finazzi / ; Maria Chiara Finazzi / ; Mara Magri / ; Giulia Quaresmini / ; Marie Lorena Guinea Montalvo / ; Clara Ricci / ; Silvia Salmoiraghi / ; Orietta Spinelli / ; Ariel Amaru / ; Josée Golay / ; Daniela Cilloni / ; Francesca Arruga / ; Enrico Bracco / ; Sonia Carturan / ; Valentina Gaidano / ; Angelo Guerrasio / ; Monica Pradotto / ; Rossella Manfredini / ; Elisa Bianchi / ; Monica Montanari / ; Simona Salati / ; Enrico Tagliafico / ; Elena Tenedini / ; Roberta Zini /
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