Document Detail

High frequency of congenital thrombophilia in women with pathological pregnancies?
MedLine Citation:
PMID:  15315591     Owner:  NLM     Status:  MEDLINE    
The obstetrical complications preeclampsia, intrauterine growth restriction (IUGR), placental abruption and fetal loss are major causes of maternal and fetal morbidity and mortality. Much recent research has focused on to what extent congenital thrombophilia contributes to these obstetrical complications. Combined with the hypercoagulable state of pregnancy, thrombophilia has the potential to induce placental thrombosis and cause placental insufficiency with subsequent obstetrical complications. This article aims to review and discuss published clinical studies of the relationship between congenital thrombophilia and preeclampsia, IUGR, placental abruption and fetal loss. In addition, the few published clinical trials of prophylactic antithrombotic treatment to prevent severe obstetrical complications in thrombophilic women are discussed. The studies have shown variable results evaluated mainly as a result of the limited number of case reports published. However, the strongest association was found to be between congenital thrombophilia and preeclampsia and late fetal loss. Early fetal loss was not found to be associated with congenital thrombophilia. At present, the question remains open as to whether IUGR and placental abruption is directly associated with thrombophilia or mediated through preeclampsia. In conclusion, the associations between congenital thrombophilia and preeclampsia, IUGR, placental abruption and fetal loss only reaches evidence grade 4. Present recommendations and clinical guidelines are thus based on weak scientific proof.
Ase Rasmussen; Pernille Ravn
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  83     ISSN:  0001-6349     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-08-18     Completed Date:  2004-10-05     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  808-17     Citation Subset:  IM    
University of Southern Denmark, Odense, Denmark.
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MeSH Terms
Fetal Death / epidemiology
Fetal Growth Retardation / diagnosis,  epidemiology*
Follow-Up Studies
Gestational Age
Infant Mortality / trends
Infant, Newborn
Maternal Mortality / trends
Obstetric Labor Complications / epidemiology
Pre-Eclampsia / diagnosis,  epidemiology
Pregnancy Complications, Hematologic / diagnosis,  epidemiology*
Pregnancy Outcome*
Risk Assessment
Severity of Illness Index
Thrombophilia / congenital*,  epidemiology*

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