| High frequency of autoimmunization among transfusion-dependent Tunisian thalassaemia patients. | |
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MedLine Citation:
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PMID: 21889408 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Limited data are available on the frequency of RBC alloimmunization and autoimmunization in transfusion-dependant Tunisian β thalassaemia patients. MATERIALS AND METHODS: We analyzed the clinical and transfusion records of 130 patients (57 females and 73 males; mean age 119months; range 12-11months) with β thalassaemia major and who had regular blood transfusions for periods ranging from 12 to 311months. RESULTS: Of the 130 patients, ten (7.7%) developed RBC alloantibodies. The most common alloantibodies were directed against antigens in the Rh systems. Erythrocyte-autoantibodies as determined by a positive direct antiglobulin Coombs test, developed in 52(40%) patients with and without underlying RBC alloantibodies, thereby causing autoimmune haemolytic anaemia in eleven patients (21%). CONCLUSIONS: Autoimmunization to erythrocyte antigens is a frequent complication in patients with β thalassaemia major. Several factors might have contributed to the high autoimmunization rate observed in this study, including non phenotypic blood exposure and alloantibody formation prior to positive Coombs test. |
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Authors:
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N Guirat-Dhouib; M Mezri; H Hmida; F Mellouli; H Kaabi; M Ouderni; B Zouari; S Hmida; M Bejaoui |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-31 |
Journal Detail:
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Title: Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis Volume: - ISSN: 1473-0502 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-9-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101095653 Medline TA: Transfus Apher Sci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Service d'immuno-hématologie pédiatrique, Centre National de Greffe de moelle osseuse 2, rue Djebel Lakhdar, Bab Saadoun 1006 -Tunis-Tunisie. |
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