Document Detail


High-frequency activity in experimental and clinical epileptic foci.
MedLine Citation:
PMID:  22024189     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pathological high-frequency electrographic activity (pHFA, >80Hz) represents one of the major discoveries in epilepsy research over the past few decades. In this review we focus on the high-frequency activity recorded in vivo in chronic models of epilepsy. The presence of HFA particularly of fast ripples (250-600Hz)reflects epileptogenic reorganization of brain tissue, endogenous epileptogenicity and ability to generate spontaneous seizures. The spatial distribution of epileptic HFA can be used to localize epileptic foci. In some regions of brain the localizing value of epileptic HFA is weakened by frequency overlap with physiological HFA. In this situation, only detailed knowledge of the regional physiological activity may provide relevant information which frequencies provide localizing information. In the epileptic hippocampus, the activity from 250Hz to 600Hz frequency band (fast ripples) is always epileptic and can be used as reliable marker of epileptic tissue in all hippocampal subregions. The localizing value of HFA in the identification of the epileptic focus is discussed from an experimental and clinical perspective; as the information provided by HFA can improve presurgical diagnosis and surgical outcome. Finally, research into HFA has contributed to improved understanding and new insights into the cellular and network organization of epileptic foci and the pathophysiology of epilepsy.
Authors:
Premysl Jiruska; Anatol Bragin
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2011-10-22
Journal Detail:
Title:  Epilepsy research     Volume:  97     ISSN:  1872-6844     ISO Abbreviation:  Epilepsy Res.     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-28     Completed Date:  2012-03-22     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  8703089     Medline TA:  Epilepsy Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  300-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier B.V. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Mapping*
Brain Waves / physiology*
Electroencephalography
Epilepsy / pathology,  physiopathology*
Hippocampus / physiopathology
Humans
Models, Biological
Grant Support
ID/Acronym/Agency:
NS065877/NS/NINDS NIH HHS; R01 NS065877/NS/NINDS NIH HHS; R01 NS065877-02/NS/NINDS NIH HHS
Comments/Corrections

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