| High frequency of MIC null haplotype (HLA-B48-MICA-del-MICB*0107 N) in the Angaite Amerindian community in Paraguay. | |
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MedLine Citation:
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PMID: 12242594 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We describe a high frequency of the MIC null haplotype, HLA-B48-MICA-del-MICB*0107 N, in the Angaite Amerindian community in Paraguay. Of the 16 unrelated subjects, 9 (56.5%) had this haplotype. The structural analyses revealed this haplotype was similar to the previously reported Asian haplotype in that they had a large-scale deletion including the entire MICA gene and linked to MICB*0107 N and HLA-B*48. The novel recombination haplotype between this MIC null haplotype and HLA-B15, HLA-B15-MICA-del-MICB*0107 N, was also found in this community. |
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Authors:
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Kayano Aida; Graciela Russomando; Mihoko Kikuchi; Norma Candia; Leticia Franco; Maria Almiron; Ratawan Ubalee; Kenji Hirayama |
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Publication Detail:
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Type: Journal Article Date: 2002-07-16 |
Journal Detail:
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Title: Immunogenetics Volume: 54 ISSN: 0093-7711 ISO Abbreviation: Immunogenetics Publication Date: 2002 Sep |
Date Detail:
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Created Date: 2002-09-20 Completed Date: 2002-11-05 Revised Date: 2005-07-19 |
Medline Journal Info:
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Nlm Unique ID: 0420404 Medline TA: Immunogenetics Country: United States |
Other Details:
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Languages: eng Pagination: 439-41 Citation Subset: IM |
Affiliation:
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Department of Medical Zoology, Saitama Medical School, Moroyama, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Base Sequence DNA / genetics Female Gene Frequency HLA-B Antigens / genetics* Haplotypes Histocompatibility Antigens Class I / genetics* Homozygote Humans Indians, South American / genetics* Linkage (Genetics) Male Paraguay Pedigree Recombination, Genetic Sequence Deletion |
| Chemical | |
Reg. No./Substance:
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0/HLA-B Antigens; 0/HLA-B15; 0/Histocompatibility Antigens Class I; 0/MHC class I-related chain A; 0/MICB antigen; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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