Document Detail


High frequency of the IL-2 -330 T/HLA-DRB1*1501 haplotype in patients with multiple sclerosis.
MedLine Citation:
PMID:  20594918     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have evaluated the role of the HLA-DRB1*1501 allele and the IL-2 -330 T/G polymorphism and their interaction in susceptibility to multiple sclerosis on 360 patients and 426 matched healthy individuals. We used the SSP-PCR method to determine the alleles. Fisher's exact test was used to analyses. We observed a significant increase in the T allele at IL-2 -330 position in patients (OR=1.34, P<0.05), and the T/T and T/G genotypes were more frequent among patients than controls. The HLA-DRB1*1501 allele was overrepresented in patients as compared to the control group (OR=1.7, P=0.0006). The two-locus analysis of the interaction between the IL-2 promoter polymorphism and the HLA-DRB1 allele showed that the HLA-DRB1*1501/T haplotype was more frequent in patients than controls (OR=16, P<0.0001). Our findings support previous findings about the role of the HLA-DRB1*1501 allele in susceptibility to MS. This work also provides new findings about the importance of gene-gene interactions in the development of MS.
Authors:
Majid Shahbazi; Danial Roshandel; Hamid Ebadi; Davood Fathi; Mahdi Zamani; Mojdeh Boghaee; Mana Mohammadhoseeeni; Azam Rshaidbaghan; Azam Bakhshandeh; Saleh Shahbazi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-07-01
Journal Detail:
Title:  Clinical immunology (Orlando, Fla.)     Volume:  137     ISSN:  1521-7035     ISO Abbreviation:  Clin. Immunol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-17     Completed Date:  2010-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883537     Medline TA:  Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  134-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Affiliation:
Medical Cellular & Molecular Research Center, Talghani Children Hospital of Golestan University of Medical Sciences, Bolv Janbazan, 4916668197, Gorgan, Iran. shahbazimajid@yahoo.co.uk
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MeSH Terms
Descriptor/Qualifier:
Adult
Age of Onset
Female
Gene Frequency / genetics
Genotype
HLA-DR Antigens / genetics*
Haplotypes / genetics*
Humans
Interleukin-2 / genetics*
Iran
Male
Middle Aged
Multiple Sclerosis / genetics*
Polymorphism, Single Nucleotide / genetics*
Severity of Illness Index
Young Adult
Chemical
Reg. No./Substance:
0/HLA-DR Antigens; 0/HLA-DRB1*1501, human; 0/Interleukin-2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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