| High frequency of the IL-2 -330 T/HLA-DRB1*1501 haplotype in patients with multiple sclerosis. | |
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MedLine Citation:
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PMID: 20594918 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have evaluated the role of the HLA-DRB1*1501 allele and the IL-2 -330 T/G polymorphism and their interaction in susceptibility to multiple sclerosis on 360 patients and 426 matched healthy individuals. We used the SSP-PCR method to determine the alleles. Fisher's exact test was used to analyses. We observed a significant increase in the T allele at IL-2 -330 position in patients (OR=1.34, P<0.05), and the T/T and T/G genotypes were more frequent among patients than controls. The HLA-DRB1*1501 allele was overrepresented in patients as compared to the control group (OR=1.7, P=0.0006). The two-locus analysis of the interaction between the IL-2 promoter polymorphism and the HLA-DRB1 allele showed that the HLA-DRB1*1501/T haplotype was more frequent in patients than controls (OR=16, P<0.0001). Our findings support previous findings about the role of the HLA-DRB1*1501 allele in susceptibility to MS. This work also provides new findings about the importance of gene-gene interactions in the development of MS. |
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Authors:
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Majid Shahbazi; Danial Roshandel; Hamid Ebadi; Davood Fathi; Mahdi Zamani; Mojdeh Boghaee; Mana Mohammadhoseeeni; Azam Rshaidbaghan; Azam Bakhshandeh; Saleh Shahbazi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-01 |
Journal Detail:
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Title: Clinical immunology (Orlando, Fla.) Volume: 137 ISSN: 1521-7035 ISO Abbreviation: Clin. Immunol. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-17 Completed Date: 2010-12-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883537 Medline TA: Clin Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 134-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Medical Cellular & Molecular Research Center, Talghani Children Hospital of Golestan University of Medical Sciences, Bolv Janbazan, 4916668197, Gorgan, Iran. shahbazimajid@yahoo.co.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age of Onset Female Gene Frequency / genetics Genotype HLA-DR Antigens / genetics* Haplotypes / genetics* Humans Interleukin-2 / genetics* Iran Male Middle Aged Multiple Sclerosis / genetics* Polymorphism, Single Nucleotide / genetics* Severity of Illness Index Young Adult |
| Chemical | |
Reg. No./Substance:
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0/HLA-DR Antigens; 0/HLA-DRB1*1501, human; 0/Interleukin-2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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