Document Detail


High frequency of EEG and MRI brain abnormalities in panic disorder.
MedLine Citation:
PMID:  9027932     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The frequency and quality of brain abnormalities in panic disorder (PD) were assessed with magnetic resonance imaging (MRI). The use of electroencephalography (EEG) to detect PD patients with a high probability of morphologic brain abnormalities was also explored. Consecutive PD patients (n = 120) were screened with routine EEG examinations and were divided into the following subgroups on the basis of their EEG findings: patients with non-epileptic EEG abnormalities (EEG-A group, n = 28), matched patients with normal EEG results (EEG-N group, n = 28) and matched healthy controls (n = 28). PD patients showed a higher than expected rate of non-epileptic EEG abnormalities (29.2%; 35 of 120). EEG screening was effective in identifying patients with a high probability of morphologic brain abnormalities. MRI abnormalities were found in 60.7% of the EEG-A patients, 17.9% of the EEG-N patients, and only 3.6% of the controls. A high frequency of septo-hippocampal abnormalities was found. Further research should focus on attempts to subtype PD on the basis of neuroanatomic and functional brain abnormalities.
Authors:
K Dantendorfer; D Prayer; J Kramer; M Amering; W Baischer; P Berger; M Schoder; K Steinberger; J Windhaber; H Imhof; H Katschnig
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Psychiatry research     Volume:  68     ISSN:  0165-1781     ISO Abbreviation:  Psychiatry Res     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-04-30     Completed Date:  1997-04-30     Revised Date:  2008-04-17    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  41-53     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, University of Vienna, Austria.
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MeSH Terms
Descriptor/Qualifier:
Adult
Brain Diseases / diagnosis*,  physiopathology,  psychology
Brain Mapping
Cerebral Cortex / abnormalities,  physiopathology
Delirium, Dementia, Amnestic, Cognitive Disorders / diagnosis*,  physiopathology,  psychology
Dominance, Cerebral / physiology
Electroencephalography*
Evoked Potentials / physiology
Female
Hippocampus / abnormalities,  physiopathology
Humans
Magnetic Resonance Imaging*
Male
Middle Aged
Panic Disorder / diagnosis*,  physiopathology,  psychology
Septum Pellucidum / abnormalities,  physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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