| High-flow oxygen therapy in acute respiratory failure. | |
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MedLine Citation:
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PMID: 20406507 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare the comfort of oxygen therapy via high-flow nasal cannula (HFNC) versus via conventional face mask in patients with acute respiratory failure. Acute respiratory failure was defined as blood oxygen saturation < 96% while receiving a fraction of inspired oxygen > or = 0.50 via face mask. METHODS: Oxygen was first humidified with a bubble humidifier and delivered via face mask for 30 min, and then via HFNC with heated humidifier for another 30 min. At the end of each 30-min period we asked the patient to evaluate dyspnea, mouth dryness, and overall comfort, on a visual analog scale of 0 (lowest) to 10 (highest). The results are expressed as median and interquartile range values. RESULTS: We included 20 patients, with a median age of 57 (40-70) years. The total gas flow administered was higher with the HFNC than with the face mask (30 [21.3-38.7] L/min vs 15 [12-20] L/min, P < .001). The HFNC was associated with less dyspnea (3.8 [1.3-5.8] vs 6.8 [4.1-7.9], P = .001) and mouth dryness (5 [2.3-7] vs 9.5 [8-10], P < .001), and was more comfortable (9 [8-10]) versus 5 [2.3-6.8], P < .001). HFNC was associated with higher P(aO(2)) (127 [83-191] mm Hg vs 77 [64-88] mm Hg, P = .002) and lower respiratory rate (21 [18-27] breaths/min vs 28 [25-32] breaths/min, P < .001), but no difference in P(aCO(2)). CONCLUSIONS: HFNC was better tolerated and more comfortable than face mask. HFNC was associated with better oxygenation and lower respiratory rate. HFNC could have an important role in the treatment of patients with acute respiratory failure. |
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Authors:
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Oriol Roca; Jordi Riera; Ferran Torres; Joan R Masclans |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article |
Journal Detail:
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Title: Respiratory care Volume: 55 ISSN: 0020-1324 ISO Abbreviation: Respir Care Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-21 Completed Date: 2010-07-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7510357 Medline TA: Respir Care Country: United States |
Other Details:
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Languages: eng Pagination: 408-13 Citation Subset: IM |
Affiliation:
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Servei de Medicina Intensiva (Area General), Hospital Universitari Vall d'Hebron, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain. oroca@ir.vhebron.net |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Catheterization* Cross-Over Studies Dyspnea / etiology, physiopathology, prevention & control Equipment Design Female Humans Intensive Care* Male Masks* Middle Aged Nasal Cavity Oxygen Inhalation Therapy / adverse effects, instrumentation* Patient Preference Respiratory Insufficiency / etiology, physiopathology, therapy* Treatment Outcome Xerostomia / etiology, physiopathology, prevention & control |
| Comments/Corrections | |
Comment In:
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Respir Care. 2010 Apr;55(4):485
[PMID:
20406519
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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