Document Detail

High flow nasal cannula therapy as respiratory support in the preterm infant.
MedLine Citation:
PMID:  19499590     Owner:  NLM     Status:  MEDLINE    
We reviewed the literature on the effects of high flow nasal cannula (HFNC) and heated, humidified, high-flow, nasal cannula (HHHFNC) treatment in preterm infants. We found nine studies, but only two were randomized controlled trials. These studies show that: HFNC application is associated to the delivery of continuous distending pressure (CDP) in patients with closed mouth, whose value is proportional to the delivered flow only in smaller infants; the CDP delivered by HFNC is unpredictable and present large inter-patient and intra-patient variability; the use of recently available HHHFNC devices is effective in minimizing nasal mucosa injuries compared to traditional HFNC; the effectiveness of HHHFNC versus NCPAP for the treatment of apnoea of prematurity, respiratory distress syndrome, and the prevention of extubation failure, has been poor investigated and firm conclusions cannot be drawn on this matter. In conclusion, on the basis of published data, the routinary application of HFNC should be limited to patients requiring oxygen-therapy, HHHFNC devices should be preferred to HFNC, but their employment as an alternative to NCPAP should wait for the conclusion of randomized controlled trials.
Carlo Dani; Simone Pratesi; Claudio Migliori; Giovanna Bertini
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Pediatric pulmonology     Volume:  44     ISSN:  1099-0496     ISO Abbreviation:  Pediatr. Pulmonol.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-29     Completed Date:  2009-10-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8510590     Medline TA:  Pediatr Pulmonol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  629-34     Citation Subset:  IM    
Division of Neonatology, Department of Surgical and Medical Critical Care, Careggi University Hospital, University of Florence School of Medicine, Viale Morgagni, 85 Firenze, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Continuous Positive Airway Pressure
Infant, Newborn
Infant, Premature*
Intubation, Intratracheal
Oxygen Inhalation Therapy / instrumentation,  methods*
Respiration, Artificial
Respiratory Distress Syndrome, Newborn / therapy
Ventilator Weaning*
Work of Breathing

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Comparison of the Sensormedics 3100A and Bronchotron transporter in a neonatal piglet ARDS model.
Next Document:  Mechanical ventilation with high tidal volume or frequency is associated with increased expression o...