| High flow nasal cannula therapy as respiratory support in the preterm infant. | |
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MedLine Citation:
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PMID: 19499590 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We reviewed the literature on the effects of high flow nasal cannula (HFNC) and heated, humidified, high-flow, nasal cannula (HHHFNC) treatment in preterm infants. We found nine studies, but only two were randomized controlled trials. These studies show that: HFNC application is associated to the delivery of continuous distending pressure (CDP) in patients with closed mouth, whose value is proportional to the delivered flow only in smaller infants; the CDP delivered by HFNC is unpredictable and present large inter-patient and intra-patient variability; the use of recently available HHHFNC devices is effective in minimizing nasal mucosa injuries compared to traditional HFNC; the effectiveness of HHHFNC versus NCPAP for the treatment of apnoea of prematurity, respiratory distress syndrome, and the prevention of extubation failure, has been poor investigated and firm conclusions cannot be drawn on this matter. In conclusion, on the basis of published data, the routinary application of HFNC should be limited to patients requiring oxygen-therapy, HHHFNC devices should be preferred to HFNC, but their employment as an alternative to NCPAP should wait for the conclusion of randomized controlled trials. |
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Authors:
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Carlo Dani; Simone Pratesi; Claudio Migliori; Giovanna Bertini |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Pediatric pulmonology Volume: 44 ISSN: 1099-0496 ISO Abbreviation: Pediatr. Pulmonol. Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-06-29 Completed Date: 2009-10-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8510590 Medline TA: Pediatr Pulmonol Country: United States |
Other Details:
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Languages: eng Pagination: 629-34 Citation Subset: IM |
Affiliation:
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Division of Neonatology, Department of Surgical and Medical Critical Care, Careggi University Hospital, University of Florence School of Medicine, Viale Morgagni, 85 Firenze, Italy. cdani@unifi.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Continuous Positive Airway Pressure Humans Humidity Infant, Newborn Infant, Premature* Intubation, Intratracheal Oxygen Inhalation Therapy / instrumentation, methods* Respiration, Artificial Respiratory Distress Syndrome, Newborn / therapy Ventilator Weaning* Work of Breathing |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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