Document Detail

High-field, T2 reversed MRI of the hippocampus in transient global amnesia.
MedLine Citation:
PMID:  15824342     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the fine structural integrity of the hippocampus in patients with transient global amnesia (TGA) using high-resolution T2 reversed (T2R) MRI. METHODS: The authors performed detailed structural analysis of the hippocampus in 15 patients who had recovered from an episode of TGA and 150 randomly recruited normal volunteers across the adult age spectrum using high-resolution T2R MRI obtained on a 3.0-T system. An additional 100 subjects, with stroke or tumor, were similarly studied and served as disease controls. RESULTS: The overall incidence of hippocampal cavities detected in normal volunteers increased with age but never exceeded 40%, whereas the incidence in disease control group was 31%. They were always unilateral. In contrast, cavities were found in all 15 patients with TGA (100%), an incidence higher than in normal or disease controls (p < 0.05; Ryan's multiple comparison test), and were bilateral in eight patients (53%). The cavities in all but one of the normal volunteers (99%) and all disease controls (100%) were crescent shaped and < or =2 mm in width. The cavities in 14 of 15 patients with TGA (93%) were considerably larger (>3 mm in width), and five of the patients had giant cavities (>5 mm in width). Most of the cavities in patients with TGA had a rounded shape and resembled pathologic cavities described in specimens of hypoxia-related CA1 necrosis. CONCLUSION: The data indicate that transient global amnesia may not be a benign entity. Delayed neuronal loss within CA1 area of Lorente de No may represent its important sequel.
Tsutomu Nakada; Ingrid L Kwee; Yukihiko Fujii; Robert T Knight
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurology     Volume:  64     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-04-12     Completed Date:  2006-02-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1170-4     Citation Subset:  AIM; IM    
Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, 1 Asahimachi, Niigata 951, Japan.
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MeSH Terms
Age Factors
Amnesia, Transient Global / diagnosis*,  epidemiology,  physiopathology
Atrophy / diagnosis*,  epidemiology,  physiopathology
Brain Damage, Chronic / diagnosis*,  epidemiology,  physiopathology
Brain Neoplasms / diagnosis
Diffusion Magnetic Resonance Imaging / methods,  standards*
Disease Progression
Functional Laterality / physiology
Hippocampus / pathology*,  physiopathology
Middle Aged
Nerve Degeneration / diagnosis,  epidemiology,  physiopathology
Predictive Value of Tests
Reference Values
Stroke / diagnosis
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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