| High-field MRI of single histological slices using an inductively coupled, self-resonant microcoil: application to ex vivo samples of patients with Alzheimer's disease. | |
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MedLine Citation:
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PMID: 20960578 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A simple inductively coupled microcoil has been designed to image tissue samples placed on a microscope slide, samples which can subsequently be stained histologically. As the exact same tissue is used for MRI and histology, the two data sets can be compared without the need for complicated image registration techniques. The design can be integrated into any MRI system using existing commercial hardware. Compared with a commercial 25-mm-diameter birdcage, the signal-to-noise ratio was increased by a factor of 3.8, corresponding to an approximate 15-fold reduction in the data acquisition time. An example is shown of ex vivo samples from patients with Alzheimer's disease, in which the coregistration of highly sensitive iron staining and amyloid-β deposits is confirmed. Copyright © 2010 John Wiley & Sons, Ltd. |
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Authors:
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Rob J A Nabuurs; Ingrid Hegeman; Remco Natté; Sjoerd G van Duinen; Mark A van Buchem; Louise van der Weerd; Andrew G Webb |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2010-10-19 |
Journal Detail:
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Title: NMR in biomedicine Volume: - ISSN: 1099-1492 ISO Abbreviation: - Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8915233 Medline TA: NMR Biomed Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Radiology, C. J. Gorter Center for High Field MRI, Leiden University Medical Center, Leiden, the Netherlands. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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