| High field (1)H MRS of the hippocampus after donepezil treatment in Alzheimer disease. | |
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MedLine Citation:
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PMID: 18252268 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to measure metabolite level changes in patients with newly diagnosed Alzheimer Disease (AD) following four months of donepezil treatment. A small number of cognitively normal elderly subjects were also scanned longitudinally (twice within one year) to assess the reproducibility. Short echo-time (1)H magnetic resonance spectra were acquired at 4.0 T in the right hippocampus. Subjects were scanned at the time of first diagnosis (prior to receiving donepezil) and then following four months of donepezil treatment (5 mg/day for the first month, 10 mg/day thereafter). Changes in absolute metabolite levels and metabolite ratios were quantified and compared. There was no change in measured cognitive function following four months of donepezil treatment in the AD patients. Decreased levels of N-acetylaspartate, choline, N-acetylaspartate/creatine, choline/creatine, and myo-inositol/creatine were observed in AD patients after four months of treatment. Cognitively normal elderly subjects showed an increase in myo-inositol/choline ratio following one year. The reduced levels of N-acetylaspartate in AD patients indicates continued decline in neuronal function and/or integrity. However decreased levels of choline and myo-inositol/creatine ratio may indicate a positive treatment effect. |
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Authors:
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Robert Bartha; Matthew Smith; Raul Rupsingh; Jane Rylett; Jennie L Wells; Michael J Borrie |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2007-12-23 |
Journal Detail:
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Title: Progress in neuro-psychopharmacology & biological psychiatry Volume: 32 ISSN: 0278-5846 ISO Abbreviation: Prog. Neuropsychopharmacol. Biol. Psychiatry Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-03-05 Completed Date: 2008-07-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8211617 Medline TA: Prog Neuropsychopharmacol Biol Psychiatry Country: England |
Other Details:
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Languages: eng Pagination: 786-93 Citation Subset: IM |
Affiliation:
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Centre for Functional and Metabolic Mapping, Robarts Research Institute, University of Western Ontario, 1151 Richmond Street, Suite 2, London, Ontario, Canada N6A 5B8. rob.bartha@imaging.robarts.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Alzheimer Disease / drug therapy, metabolism*, pathology Aspartic Acid / metabolism Brain Chemistry / drug effects Choline / metabolism Cholinesterase Inhibitors / pharmacology*, therapeutic use Creatine / metabolism Female Hippocampus / drug effects*, metabolism Humans Indans / pharmacology*, therapeutic use Inositol / metabolism Magnetic Resonance Spectroscopy / methods Male Piperidines / pharmacology*, therapeutic use Protons / diagnostic use |
| Chemical | |
Reg. No./Substance:
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0/Cholinesterase Inhibitors; 0/Indans; 0/Piperidines; 0/Protons; 120011-70-3/donepezil; 56-84-8/Aspartic Acid; 57-00-1/Creatine; 62-49-7/Choline; 6917-35-7/Inositol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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