Document Detail

High field (1)H MRS of the hippocampus after donepezil treatment in Alzheimer disease.
MedLine Citation:
PMID:  18252268     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to measure metabolite level changes in patients with newly diagnosed Alzheimer Disease (AD) following four months of donepezil treatment. A small number of cognitively normal elderly subjects were also scanned longitudinally (twice within one year) to assess the reproducibility. Short echo-time (1)H magnetic resonance spectra were acquired at 4.0 T in the right hippocampus. Subjects were scanned at the time of first diagnosis (prior to receiving donepezil) and then following four months of donepezil treatment (5 mg/day for the first month, 10 mg/day thereafter). Changes in absolute metabolite levels and metabolite ratios were quantified and compared. There was no change in measured cognitive function following four months of donepezil treatment in the AD patients. Decreased levels of N-acetylaspartate, choline, N-acetylaspartate/creatine, choline/creatine, and myo-inositol/creatine were observed in AD patients after four months of treatment. Cognitively normal elderly subjects showed an increase in myo-inositol/choline ratio following one year. The reduced levels of N-acetylaspartate in AD patients indicates continued decline in neuronal function and/or integrity. However decreased levels of choline and myo-inositol/creatine ratio may indicate a positive treatment effect.
Robert Bartha; Matthew Smith; Raul Rupsingh; Jane Rylett; Jennie L Wells; Michael J Borrie
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-12-23
Journal Detail:
Title:  Progress in neuro-psychopharmacology & biological psychiatry     Volume:  32     ISSN:  0278-5846     ISO Abbreviation:  Prog. Neuropsychopharmacol. Biol. Psychiatry     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-05     Completed Date:  2008-07-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211617     Medline TA:  Prog Neuropsychopharmacol Biol Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  786-93     Citation Subset:  IM    
Centre for Functional and Metabolic Mapping, Robarts Research Institute, University of Western Ontario, 1151 Richmond Street, Suite 2, London, Ontario, Canada N6A 5B8.
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MeSH Terms
Aged, 80 and over
Alzheimer Disease / drug therapy,  metabolism*,  pathology
Aspartic Acid / metabolism
Brain Chemistry / drug effects
Choline / metabolism
Cholinesterase Inhibitors / pharmacology*,  therapeutic use
Creatine / metabolism
Hippocampus / drug effects*,  metabolism
Indans / pharmacology*,  therapeutic use
Inositol / metabolism
Magnetic Resonance Spectroscopy / methods
Piperidines / pharmacology*,  therapeutic use
Protons / diagnostic use
Reg. No./Substance:
0/Cholinesterase Inhibitors; 0/Indans; 0/Piperidines; 0/Protons; 120011-70-3/donepezil; 56-84-8/Aspartic Acid; 57-00-1/Creatine; 62-49-7/Choline; 6917-35-7/Inositol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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