Document Detail


High fetal splenic artery peak velocity in fetuses with hemoglobin Bart disease: a preliminary study.
MedLine Citation:
PMID:  19106351     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The purpose of this study was to evaluate the role of the splenic artery (SPA) peak systolic velocity (PSV) in identifying fetuses with hemoglobin (Hb) Bart disease among pregnancies at risk for the disease. METHODS: Pregnancies at risk for fetal Hb Bart disease scheduled for cordocentesis at 18 to 25 weeks' gestation at Maharaj Nakorn Chiang Mai Hospital were recruited into the study. The SPA PSV was measured before cordocentesis, and the final fetal diagnosis of Hb Bart disease was based on fetal Hb typing using high-performance liquid chromatography. RESULTS: Seventy-six singleton pregnancies at risk for fetal Hb Bart disease were sonographically evaluated for the SPA PSV and underwent cordocentesis for fetal blood analysis. Among the 76 recruited pregnancies, 17 fetuses with Hb Bart disease were finally diagnosed by fetal blood analysis with high-performance liquid chromatography, and the remainder had no abnormalities or had the alpha-thalassemia 1 trait and were defined as unaffected fetuses. The mean SPA PSVs +/- SD for the unaffected and affected fetuses were significantly different: 21.17 +/- 3.7 cm/s (range, 13.8-29.9 cm/s) and 26.12 +/- 3.6 cm/s (range, 20.4-31.5 cm/s) respectively. The SPA PSV of the affected fetuses was higher than that of the unaffected ones (Wilcoxon signed rank test, P < .001). CONCLUSIONS: Splenic artery PSV assessment at mid pregnancy may have a potential role in identifying fetuses with Hb Bart disease. Further studies to evaluate the effectiveness of the SPA PSV in differentiating affected from unaffected fetuses among pregnancies at risk are desirable.
Authors:
Theera Tongsong; Fuanglada Tongprasert; Kasemsri Srisupundit; Suchaya Luewan
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine     Volume:  28     ISSN:  1550-9613     ISO Abbreviation:  J Ultrasound Med     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-24     Completed Date:  2009-02-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211547     Medline TA:  J Ultrasound Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  13-8     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand. ttongson@mail.med.cmu.ac.th
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MeSH Terms
Descriptor/Qualifier:
Hemoglobinopathies / embryology*,  ultrasonography*
Hemoglobins, Abnormal*
Humans
Pilot Projects
Reproducibility of Results
Sensitivity and Specificity
Splenic Artery / ultrasonography*
Ultrasonography, Doppler / methods*
Ultrasonography, Prenatal / methods*
Chemical
Reg. No./Substance:
0/Hemoglobins, Abnormal; 9056-09-1/hemoglobin Bart's

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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