| High fetal plasma adenosine concentration: a role for the fetus in preeclampsia? | |
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MedLine Citation:
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PMID: 21855848 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Clinical observations suggest a role for the fetus in the maternal manifestations of preeclampsia, but the possible signaling mechanisms remain unclear. This study compares the fetal plasma concentrations of adenosine from normal pregnancies with those from preeclampsia. STUDY DESIGN: This secondary data analysis included normal pregnancies (n = 27) and patients with preeclampsia (n = 39). Patients with preeclampsia were subclassified into patients with (n = 25) and without (n = 14) abnormal uterine artery Doppler velocimetry (UADV). RESULTS: Fetal plasma concentrations of adenosine were significantly higher in patients with preeclampsia (1.35 ± 0.09 μmol/L) than in normal pregnancies (0.52 ± 0.06 μmol/L; P < .0001). Fetal plasma concentrations of adenosine in patients with preeclampsia with abnormal UADV (1.78 ± 0.15 μmol/L), but not with normal UADV (0.58 ± 0.14 μmol/L), were significantly higher than in normal pregnancies (P < .0001). CONCLUSION: Patients with preeclampsia with sonographic evidence of chronic uteroplacental ischemia have high fetal plasma concentrations of adenosine. |
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Authors:
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Jimmy Espinoza; Andres F Espinoza; Gordon G Power |
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Publication Detail:
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Type: Journal Article Date: 2011-06-15 |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 205 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-10-31 Completed Date: 2012-01-17 Revised Date: 2012-05-07 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 485.e24-7 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2011 Mosby, Inc. All rights reserved. |
Affiliation:
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Department of Obstetrics and Gynecology, William Beaumont Hospital, Royal Oak Michigan and Oakland University, Rochester, MI, USA. jimmy.espinoza@beaumont |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine
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blood* Adult Female Fetal Blood / metabolism* Humans Pre-Eclampsia / blood, etiology* Pregnancy Uterine Artery |
| Chemical | |
Reg. No./Substance:
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58-61-7/Adenosine |
| Comments/Corrections | |
Comment In:
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Am J Obstet Gynecol. 2012 Apr;206(4):e5-6; author reply e6-7
[PMID:
22281430
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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