Document Detail

High-fat meals increase the clearance of cyclosporine.
MedLine Citation:
PMID:  2300535     Owner:  NLM     Status:  MEDLINE    
High-fat meals increase the clearance and volume of distribution, but not the mean residence time, of cyclosporine in seven healthy volunteers when either plasma or blood analyses are used. This unexpected finding for a low-extraction ratio drug should not be explainable in terms of increased blood flow. We hypothesize that dietary fat can act as a carrier for cyclosporine and enhance both its volume of distribution and its clearance. We suggest that clearance then occurs following metabolism of lipids due to lipase activity within the hepatocyte, thereby releasing free drug for metabolism.
S K Gupta; L Z Benet
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pharmaceutical research     Volume:  7     ISSN:  0724-8741     ISO Abbreviation:  Pharm. Res.     Publication Date:  1990 Jan 
Date Detail:
Created Date:  1990-03-12     Completed Date:  1990-03-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8406521     Medline TA:  Pharm Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  46-8     Citation Subset:  IM    
Department of Pharmacy, School of Pharmacy, University of California, San Francisco 94143-0446.
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MeSH Terms
Biological Availability
Cyclosporins / pharmacokinetics*
Dietary Fats / administration & dosage*
Grant Support
Reg. No./Substance:
0/Cyclosporins; 0/Dietary Fats

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