Document Detail

High-fat, low-carbohydrate diet promotes arrhythmic death and increases myocardial ischemia-reperfusion injury in rats.
MedLine Citation:
PMID:  24929857     Owner:  NLM     Status:  Publisher    
High fat, low carbohydrate diets (HFLCD) are often eaten by humans for a variety of reasons, but the effects of such diets on the heart are incompletely understood. We evaluated the impact of HFLCD on myocardial ischemia / reperfusion (I/R) using an in vivo model of left anterior descending (LAD) coronary artery ligation. 300 gram Sprague-Dawley rats were fed HFLCD (60% calories fat, 30% protein, 10% carbohydrate) or control (CONT; 16% / 19% / 65%) diet for 2 weeks, then underwent open chest I/R. At baseline (pre-ischemia), diet did not affect left ventricular (LV) systolic and diastolic function. Oil red O staining revealed presence of lipid in the heart with HFLCD but not in CONT. Following I/R, recovery of LV function was decreased in HFLCD. HFLCD hearts exhibited decreased ATP synthase and increased uncoupling protein-3 (UCP3) gene and protein expression. HFLCD down-regulated mitochondrial fusion proteins, and upregulated fission proteins and store-operated Ca(2+) channel proteins. HFLCD led to increased death during I/R: 6 of 22 CONT rats and 16 of 26 HFLCD rats died, due to ventricular arrhythmias and hemodynamic shock. In surviving rats, HFLCD led to larger infarct size. We concluded that in vivo, HFLCD does not affect non-ischemic LV function, but leads to greater myocardial injury during I/R, with increased risk of death by pump failure and ventricular arrhythmias, which might be associated with altered cardiac energetics, mitochondrial fission/fusion dynamics, and store-operated Ca(2+) channel expression.
Jian Liu; Peipei Wang; Luyun Zou; Jing Qu; Silvio H Litovsky; Patrick K Umeda; Lufang Zhou; John C Chatham; Susan A Marsh; Louis J Dell'Italia; Steven G Lloyd
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-6-13
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  -     ISSN:  1522-1539     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-6-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014, American Journal of Physiology - Heart and Circulatory Physiology.
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