Document Detail

High fat food increases gastric residence and thus thresholds for objective symptoms in allergic patients.
MedLine Citation:
PMID:  22997185     Owner:  NLM     Status:  Publisher    
SCOPE: We have tested the hypothesis that high fat foods such as chocolate induce reduced rates of gastric emptying in comparison to lower fat foods and that this can impact uptake of allergens and subsequent reactions in allergic patients. METHODS AND RESULTS: In four volunteers, magnetic resonance imaging was used to measure gastric emptying of a series of nine doses of either dark chocolate bars containing 35% fat or a chocolate dessert containing 8% fat. Analysis showed a mean rate of decrease in gastric volume with an 8% fat dessert was 0.33 ± 0.09 mL/min compared to an average rate of increase in gastric volume of 0.09 ± 0.10 mL/min for the chocolate bars. In parallel, eight allergic patients were challenged for either peanut or hazelnut in the same two matrices and doses using a standardized protocol. A statistical analysis of the objective symptoms in the allergic patients showed that the chocolate bars gave a significantly higher threshold for objective symptoms than the dessert. CONCLUSIONS: Chocolate bars induced lower gastric emptying rates and in food challenges with allergic patients gave a higher threshold of elicitation for objective reactions than a dessert.
Alan Mackie; Andre Knulst; Thuy-My Le; Peter Bures; Louise Salt; E N Clare Mills; Paul Malcolm; Adrian Andreou; Barbara K Ballmer-Weber
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-19
Journal Detail:
Title:  Molecular nutrition & food research     Volume:  -     ISSN:  1613-4133     ISO Abbreviation:  Mol Nutr Food Res     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101231818     Medline TA:  Mol Nutr Food Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Institute of Food Research, Norwich Research Park, Colney, Norwich, UK.
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