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High-fat feeding during gestation and nursing period have differential effects on the insulin secretory capacity in offspring from normal Wistar rats.
MedLine Citation:
PMID:  17491688     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Restriction of protein or energy intake during gestation or early life is linked to developmental defects in the endocrine pancreas and insulin resistance. AIMS: To study whether a saturated fatty acid-rich diet during gestation and/or after the weaning period may be detrimental to the insulin secretory capacity later in life. STUDY DESIGN: Female Wistar rats were fed diets rich in carbohydrate (CHO) or saturated fat (SAFA) during pregnancy. The male offspring were split into five subgroups: after birth group 1 (control) continued on CHO and group 3 on SAFA. Group 2 continued on the CHO diet during the nursing period but changed to SAFA post weaning. Group 4 continued on SAFA, but changed to CHO post weaning. For group 5 the offspring of mothers given a SAFA diet were changed to nursing mothers on a CHO diet immediately after birth, and continued on the same diet post weaning. After 14 wk, the islets of Langerhans were isolated for determination of insulin secretory capacity in static incubation and dynamic perifusion experiments. RESULTS: We found a negative correlation (Coef: -3.1, 95% CI: -6.1 to -0.0, p < 0.05) between a diet rich in saturated fat fed to mothers during gestation and a positive correlation (Coef: 4.4, 95% CI: 0.9 to 7.8, p = 0.01) between nursing mothers' diet and the capability to secrete insulin in the offspring. CONCLUSION: Our results indicate the importance of applying a nutrient-balanced diet during pregnancy and the nursing period on the later insulin secretory capacity in the offspring.
Authors:
Stig E U Dyrskog; Søren Gregersen; Kjeld Hermansen
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Publication Detail:
Type:  Journal Article     Date:  2005-11-10
Journal Detail:
Title:  The review of diabetic studies : RDS     Volume:  2     ISSN:  1614-0575     ISO Abbreviation:  -     Publication Date:  2005  
Date Detail:
Created Date:  2007-05-11     Completed Date:  2007-08-10     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  101227575     Medline TA:  Rev Diabet Stud     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  136-45     Citation Subset:  -    
Affiliation:
Department of Endocrinology and Metabolism C, Aarhus Sygehus THG, Aarhus University Hospital, Tage-Hansens Gade 2, 8000 Aarhus C, Denmark. stig.dyrskog@ki.au.dk
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