| High-fat diet overrules the effects of training on fiber-specific intramyocellular lipid utilization during exercise. | |
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MedLine Citation:
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PMID: 21551007 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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In this study we compared the effects of endurance training in the fasted state versus the fed state, on exercise-induced intramyocellular lipid (IMCL) and glycogen utilization during a 6-week period of hypercaloric (~+30% kcal/day) fat-rich diet (50% of kcal; HFD). Healthy male volunteers (18-25yrs) received HFD in conjunction with endurance training (4 times 60-90 min per week) either in the fasted state (F; n=10), or with ample carbohydrate intake before and during exercise sessions (CHO; n=10). The control group (CON; n=7) received HFD without training and increased body weight by ~3kg (P<0.001). Before and after HFD, the subjects performed a 2-hr constant-load bicycle exercise test in the fasted state @ ~70% VO(2)max. HFD, both in the absence or presence of training (F or CHO), elevated basal IMCL content by ~50% in type I and by ~75% in type IIa fibers (P<0.05). Independent of training in F or CHO, HFD as such stimulated exercise-induced net IMCL breakdown by ~2-fold in type I and by ~4-fold in type IIa fibers. Furthermore, exercise-induced net muscle glycogen breakdown was not significantly affected by HFD. It is concluded that HFD stimulates net IMCL degradation, by increasing basal IMCL content, during exercise in type I and especially IIa fibers. Furthermore, a hypercaloric HFD provides adequate amounts of carbohydrates to maintain high muscle glycogen content during training and does not impair exercise-induced muscle glycogen breakdown. |
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Authors:
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Karen Van Proeyen; Karolina Szlufcik; Henri Nielens; Louise Deldicque; Raf Van Dyck; Monique Ramaekers; Peter Hespel |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-5 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: - ISSN: 1522-1601 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1K.U.Leuven. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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