| HIGH FAT DIET IS ASSOCIATED WITH BLUNTED SPLANCHNIC SYMPATHOINHIBITORY RESPONSES TO GASTRIC LEPTIN AND CHOLECYSTOKININ: IMPLICATIONS FOR CIRCULATORY CONTROL. | |
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MedLine Citation:
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PMID: 21239630 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Gastric leptin and cholecystokinin (CCK) act on vagal afferents to induce cardiovascular effects and reflex inhibition of splanchnic sympathetic nerve discharge (SSND), and may act co-operatively in these responses. We sought to determine whether these effects are altered in animals that developed obesity in response to a medium high fat diet (MHFD). Male Sprague-Dawley rats were placed on a low-fat diet (LFD; n=8) or a MHFD (n=24) for 13 weeks, after which animals were anesthetised and artificially ventilated. Arterial pressure (AP) was monitored and blood was collected for determination of plasma leptin and CCK. SSND responses to leptin (15 μg/kg) and CCK (2 μg/kg) administered close to the coeliac artery were evaluated. Collectively, MHFD animals had significantly higher plasma leptin but lower plasma CCK levels than LFD rats (P < 0.05) and this corresponded to attenuated or reversed SSND responses to CCK (LFD: -21 ± 2%; MHFD: -12 ± 2 %; P < 0.05) and leptin (LFD: -6 ± 2%; MHFD: 4 ± 1 %; P < 0.001). Alternatively, animals on the MHFD were stratified into obesity-prone (OP; n=8) or obesity-resistant (OR; n=8) groups according to their weight gain falling within the upper or lower tertile, respectively. OP rats had significantly higher resting AP, adiposity and plasma leptin but lower plasma CCK compared to LFD rats (P < 0.05). The SSND responses to CCK or leptin were not significantly different between OP and OR animals.These results demonstrate that a high fat diet is associated with blunted splanchnic sympathoinhibitory responses to gastric leptin and cholecystokinin, and may impact on sympathetic vasomotor mechanisms involved in circulatory control. |
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Authors:
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Jackie M Y How; Barbara C Fam; Anthony J M Verberne; Daniela M Sartor |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-14 |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: - ISSN: 1522-1539 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1University of Melbourne. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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