Document Detail


High factor XI, recurrent pregnancy loss, enoxaparin.
MedLine Citation:
PMID:  21094629     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Of the 149 women with 0 pregnancy losses, 7 (5%) had factor XI level ≥150% versus 5 of 31 (16%) women with recurrent pregnancy loss. Three of the 5 women with high factor XI and recurrent pregnancy loss, with 19 previous pregnancy losses and 0 live births, were given enoxaparin during 5 subsequent pregnancies, and had 6 term live births and 1 miscarriage.
Authors:
Charles J Glueck; Joel Pranikoff; Naseer Khan; Kashif Riaz; Kirti Chavan; Pavithra Raj; Muhammad Umar; Ping Wang
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-06-17
Journal Detail:
Title:  Fertility and sterility     Volume:  94     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-26     Completed Date:  2011-01-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2828-31     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Affiliation:
Cholesterol Center, Jewish Hospital, Cincinnati, Ohio 45229, USA. glueckch@healthall.com
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MeSH Terms
Descriptor/Qualifier:
Abortion, Habitual / blood*,  epidemiology,  genetics,  prevention & control*
Anticoagulants / therapeutic use
Cohort Studies
Embryo Loss / blood,  epidemiology,  genetics,  prevention & control
Enoxaparin / administration & dosage,  therapeutic use*
Factor XI / analysis,  metabolism*
Female
Homozygote
Humans
Methylenetetrahydrofolate Reductase (NADPH2) / genetics
Mutation, Missense
Pregnancy
Pregnancy Complications, Hematologic / blood,  drug therapy,  epidemiology
Pregnancy Rate
Up-Regulation
Grant Support
ID/Acronym/Agency:
//Medical Research Council
Chemical
Reg. No./Substance:
0/Anticoagulants; 0/Enoxaparin; 9013-55-2/Factor XI; EC 1.5.1.20/Methylenetetrahydrofolate Reductase (NADPH2)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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