Document Detail

High factor VIII and the risk of venous thromboembolism.
MedLine Citation:
PMID:  12567199     Owner:  NLM     Status:  MEDLINE    
There is now convincing evidence that a high level of coagulation factor VIII is an important risk factor for venous thromboembolism. A factor VIII plasma concentration above 1500 IU/l is associated with an almost 5-fold risk for a first episode of venous thrombosis. In thrombosis patients high factor VIII has been shown to persist over time and is not related to an acute phase reaction. High factor VIII is also an important risk factor for recurrence of venous thrombosis. In a prospective cohort study factor VIII levels exceeding the 90th percentile of the patient population conferred an almost 7-fold risk of recurrent venous thrombosis. The pathomechanisms leading to venous thrombosis in patients with high factor VIII are still unclear. In many patients, however, a biochemically detectable hypercoagulable state (as represented by elevated levels of the coagulation activation marker prothrombin thrombin fragment F1.2) was demonstrated. The optimal duration of secondary thromboprophylaxis for patients with high factor VIII levels is uncertain. We currently perform an interventional trial comparing conventional to extended anticoagulation. Reduction of factor VIII by administration of a non-selective ss-receptor blocker might be a promising therapeutic concept which is currently under investigation.
Paul A Kyrle
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hämostaseologie     Volume:  23     ISSN:  0720-9355     ISO Abbreviation:  Hamostaseologie     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-02-04     Completed Date:  2003-03-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8204531     Medline TA:  Hamostaseologie     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  41-4     Citation Subset:  IM    
Department of Hematology and Hemostasis, Vienna Medical School, Austria.
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MeSH Terms
Factor VIII / metabolism*
Risk Factors
Thromboembolism / epidemiology*,  etiology
Venous Thrombosis / epidemiology*,  etiology
Reg. No./Substance:
9001-27-8/Factor VIII

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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