Document Detail

High expression level of bone degrading proteins as a possible inducer of osteolytic features in pigmented villonodular synovitis.
MedLine Citation:
PMID:  17601661     Owner:  NLM     Status:  MEDLINE    
Protein expression of osteopontin (OPN), osteoprotegerin (OPG), bone sialoprotein (BSP), osteocalcin (OC), RANKL and PTHrP was determined by use of immunohistochemical analysis on tissue arrays (48 cases of PVNS, 20 cases of active (a-RA), non-active rheumatoid arthritis (na-RA), and osteoarthritis (OA)). Additionally, gene expression was analysed using complimentary DNA (cDNA) microarrays. All PVNS cases showed a higher level of both protein and gene expression of RANKL, OPN and BSP in comparison with OA cases. Expression of OPG was not significantly different in PVNS compared to OA. The RANKL/OPG expression ratio was significantly higher in PVNS than in OA. High expressions level of proteins involved in bone degradation in PVNS may promote an intra-osseous propagation of the lesion. This evidence suggests that PVNS might respond to treatment using specific inhibitors of RANKL, OPN and BSP.
Aman Geldyyev; Nadezda Koleganova; Grzegorz Piecha; Holger Sueltmann; Katharina Finis; Markus Ruschaupt; Annemarie Poustka; Marie-Luise Gross; Irina Berger
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-06-29
Journal Detail:
Title:  Cancer letters     Volume:  255     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-08-27     Completed Date:  2007-11-09     Revised Date:  2010-02-04    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  275-83     Citation Subset:  IM    
Institute for Pathology, University of Heidelberg, Germany.
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MeSH Terms
Biological Markers / analysis,  metabolism
Middle Aged
Osteoarthritis / metabolism
Osteolysis / etiology,  metabolism*
Osteopontin / analysis,  genetics,  metabolism*
Osteoprotegerin / analysis,  genetics,  metabolism
RANK Ligand / analysis,  genetics,  metabolism*
Sialoglycoproteins / analysis,  genetics,  metabolism*
Synovitis, Pigmented Villonodular / complications*
Tissue Array Analysis
Reg. No./Substance:
0/Biological Markers; 0/Osteoprotegerin; 0/RANK Ligand; 0/Sialoglycoproteins; 0/integrin-binding sialoprotein; 106441-73-0/Osteopontin; 63231-63-0/RNA

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