Document Detail

High expression level of EDIL3 in HCC predicts poor prognosis of HCC patients.
MedLine Citation:
PMID:  20857535     Owner:  NLM     Status:  MEDLINE    
AIM: To determine the role of epidermal growth factor-like repeats and discoidin I-like domains 3 (EDIL3) in pathogenesis of hepatocellular carcinoma (HCC) by investigating the EDIL3 expression in HCC and its prognostic value for HCC.
METHODS: EDIL3 expression was detected in 101 HCC surgical tissue samples with immunohistochemistry method, and its relation with clinicopathologic features and prognosis of HCC patients was analyzed.
RESULTS: EDIL3 was highly expressed in 48.5% of the HCC patients. Although the EDIL3 expression level did not correlate with any clinicopathological parameters, Kaplan-Meier survival analysis showed that high expression level of EDIL3 resulted in a significantly poor prognosis of HCC patients (log-rank test, P = 0.010). Multivariate Cox's analysis showed that the EDIL3 expression level was a significant and independent prognostic parameter for the overall survival rate of HCC patients (hazard ratio = 1.978, 95% confidence interval = 1.139-3.435, P = 0.015).
CONCLUSION: High expression level of EDIL3 predicts poor prognosis of HCC patients. EDIL3 may be a potential target of antiangiogenic therapy for HCC.
Jian-Cong Sun; Xiao-Ting Liang; Ke Pan; Hui Wang; Jing-Jing Zhao; Jian-Jun Li; Hai-Qing Ma; Yi-Bing Chen; Jian-Chuan Xia
Related Documents :
1650535 - Experience with 225 hepatic resections for hepatocellular carcinoma over a 4-year period.
12649165 - A 6-month versus a 12-month surveillance for hepatocellular carcinoma in 559 hemophilia...
15561225 - The significance of transarterial embolization for advanced hepatocellular carcinoma in...
17135305 - Diastolic dysfunction is associated with poor survival in patients with cirrhosis with ...
12820355 - Carcinoembryonic antigen (cea)--a useful marker for the detection of recurrent disease ...
24406425 - The prognosis of incurable cachectic cancer patients on home parenteral nutrition: a mu...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  16     ISSN:  2219-2840     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-21     Completed Date:  2011-01-28     Revised Date:  2014-05-20    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  4611-5     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Carcinoma, Hepatocellular / diagnosis,  metabolism*,  pathology
Carrier Proteins / metabolism*
Middle Aged
Survival Rate
Tumor Markers, Biological / metabolism*
Reg. No./Substance:
0/Carrier Proteins; 0/EDIL3 protein, human; 0/Tumor Markers, Biological

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Laparoscopic low anterior resection for rectal carcinoma: complications and management in 132 consec...
Next Document:  Clinicopathological features of gastric glomus tumor.