Document Detail


High expression level of EDIL3 in HCC predicts poor prognosis of HCC patients.
MedLine Citation:
PMID:  20857535     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To determine the role of epidermal growth factor-like repeats and discoidin I-like domains 3 (EDIL3) in pathogenesis of hepatocellular carcinoma (HCC) by investigating the EDIL3 expression in HCC and its prognostic value for HCC.
METHODS: EDIL3 expression was detected in 101 HCC surgical tissue samples with immunohistochemistry method, and its relation with clinicopathologic features and prognosis of HCC patients was analyzed.
RESULTS: EDIL3 was highly expressed in 48.5% of the HCC patients. Although the EDIL3 expression level did not correlate with any clinicopathological parameters, Kaplan-Meier survival analysis showed that high expression level of EDIL3 resulted in a significantly poor prognosis of HCC patients (log-rank test, P = 0.010). Multivariate Cox's analysis showed that the EDIL3 expression level was a significant and independent prognostic parameter for the overall survival rate of HCC patients (hazard ratio = 1.978, 95% confidence interval = 1.139-3.435, P = 0.015).
CONCLUSION: High expression level of EDIL3 predicts poor prognosis of HCC patients. EDIL3 may be a potential target of antiangiogenic therapy for HCC.
Authors:
Jian-Cong Sun; Xiao-Ting Liang; Ke Pan; Hui Wang; Jing-Jing Zhao; Jian-Jun Li; Hai-Qing Ma; Yi-Bing Chen; Jian-Chuan Xia
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  16     ISSN:  2219-2840     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-21     Completed Date:  2011-01-28     Revised Date:  2014-05-20    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  4611-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Carcinoma, Hepatocellular / diagnosis,  metabolism*,  pathology
Carrier Proteins / metabolism*
Female
Humans
Immunohistochemistry
Male
Middle Aged
Prognosis
Survival Rate
Tumor Markers, Biological / metabolism*
Chemical
Reg. No./Substance:
0/Carrier Proteins; 0/EDIL3 protein, human; 0/Tumor Markers, Biological
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