Document Detail


High expression of human telomerase reverse transcriptase in high-grade intraepithelial neoplasia and carcinoma of uterine cervix and its correlation with human papillomavirus infection.
MedLine Citation:
PMID:  17644806     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Most of cervical intraepithelial neoplasia 1 (CIN 1) will regress and 12% to 40% of high-grade CIN may progress to squamous cell carcinoma (SCC) of the uterine cervix. However, the differentiation of CIN 1 and high-grade CIN is sometimes controversial among pathologists. Human telomerase reverse transcriptase (hTERT) is therefore applied to detect the differences among normal, CIN 1, high-grade CIN, and SCC tissues of uterine cervix. One hundred six cervical specimens were collected for immunohistochemical study of hTERT. These data were compared with the human papillomavirus (HPV) DNA status. Expression of hTERT in high-grade CIN increased significantly compared to that in CIN 1 ( P < .001). A positive relationship was found between high hTERT expression and degree of malignant transformation ( P < .001). Most of the cases with high hTERT expression tested positive for the high-risk HPV groups. High hTERT expression was detected in 88.73% of the samples with cervical high-grade CIN or SCC. Low hTERT expression was found in 94.29% of low-grade CIN or normal tissues. Furthermore, 96.92% of the cervical tissues with high hTERT expression were high-grade CIN or SCC. A total of 80.49% of samples with low hTERT expression were low-grade CIN or normal tissues. A significantly increased hTERT expression between CIN 1 and high-grade CIN exhibits a critical progression in cervical carcinogenesis. hTERT can be offered as additional molecular information correlated with more severe dysplasia and SCC. Furthermore, this increased hTERT expression is correlated whigh-risk HPVs infection.
Authors:
Po-Hui Wang; Gin-Den Chen; Han Chang; Shun-Fa Yang; Chih-Ping Han; Long-Yau Lin; Jiunn-Liang Ko
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Reproductive sciences (Thousand Oaks, Calif.)     Volume:  14     ISSN:  1933-7205     ISO Abbreviation:  Reprod Sci     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-07-23     Completed Date:  2007-09-26     Revised Date:  2008-01-21    
Medline Journal Info:
Nlm Unique ID:  101291249     Medline TA:  Reprod Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  338-48     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Chung Shan Medical University Taichung, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Carcinoma in Situ / enzymology,  genetics*
Cell Line, Tumor
Cervix Uteri / enzymology
DNA, Neoplasm / genetics
Female
Gene Expression Regulation, Enzymologic
Humans
Papillomavirus Infections / genetics*
Polymerase Chain Reaction
Reference Values
Telomerase / genetics*
Uterine Cervical Neoplasms / enzymology,  genetics*
Chemical
Reg. No./Substance:
0/DNA, Neoplasm; EC 2.7.7.49/Telomerase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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