| High expression of an N-acetylglucosaminyltransferase III in 3'-methyl DAB-induced hepatoma and ascites hepatoma. | |
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MedLine Citation:
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PMID: 2981047 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ascites hepatoma AH-66 and 3'-Me-DAB-induced hepatoma of rats contain highly active N-acetylglucosaminyltransferase III (GnT-III) which catalyzes the addition of N-acetylglucosamine through a beta 1-4 linkage (bisecting N-acetylglucosamine) to the beta-linked mannose of the trimannosyl core of asparagine-linked sugar chains, whereas normal rat liver contains very little. The high activity was also detected in fetal rat liver, newborn rat liver, hyperplastic nodules and various transplantable hepatomas. |
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Authors:
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A Nishikawa; S Fujii; T Sugiyama; N Hayashi; N Taniguchi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 152 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1988 Apr |
Date Detail:
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Created Date: 1988-05-24 Completed Date: 1988-05-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 107-12 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, Osaka University Medical School, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging Animals Animals, Newborn Carbohydrate Conformation Carbohydrate Sequence Female Fetus Glucosyltransferases / metabolism* Liver / enzymology, growth & development Liver Neoplasms, Experimental / enzymology* Liver Regeneration Male Methyldimethylaminoazobenzene Molecular Sequence Data N-Acetylglucosaminyltransferases Oligosaccharides / biosynthesis Pregnancy Rats Rats, Inbred Strains Substrate Specificity |
| Chemical | |
Reg. No./Substance:
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0/Oligosaccharides; 55-80-1/Methyldimethylaminoazobenzene; EC 2.4.1.-/Glucosyltransferases; EC 2.4.1.-/N-Acetylglucosaminyltransferases; EC 2.4.1.144/beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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