| High eradication rate of Helicobacter pylori using a four-drug regimen in patients previously treated unsuccessfully. | |
| | |
MedLine Citation:
|
PMID: 9385479 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The objective of this study was to assess the efficacy of a new regimen in eradicating Helicobacter pylori (Hp) in patients with duodenal ulcer (DU) who were previously treated unsuccessfully with standard triple therapy (tripotassium dicitratobismuthate [TDB] 120 mg QID, metronidazole 500 mg TID, and tetracycline 500 mg QID) or proton-pump inhibitor (PPI) dual therapy (omeprazole 20 mg BID and amoxicillin 500 mg QID). The study included 133 consecutive patients aged 17 to 83 years with endoscopically diagnosed DU (diameter > or = 5 mm) in whom standard triple therapy or PPI dual therapy had failed to eradicate Hp. A rapid urease (CLO) test was performed on four biopsy specimens at study entry and at least 1 month after the end of treatment to confirm Hp colonization and eradication, respectively. Patients were considered to be Hp positive if any CLO test was positive within 2 hours, and Hp was considered to be eradicated if all CLO tests were still negative after 24 hours. In 31 randomly selected patients, Hp eradication was confirmed histologically as well. Patients were given omeprazole 60 mg/d (20 mg in the morning and 40 mg in the evening) plus amoxicillin 500 mg QID for 10 days and subsequently were given metronidazole 500 mg TID for 10 days plus TDB 120 mg QID for 6 weeks. One hundred and twenty-four patients were followed up; five (4%) withdrew because of side effects (protracted diarrhea, stomatitis, skin rashes). Per-protocol analysis showed Hp eradication in 113 of 119 patients (95%) and ulcer healing in 118 of 119 (99%). Intent-to-treat analysis showed an Hp eradication rate of 85% (113 of 133 patients) and an ulcer healing rate of 89% (118 of 133 patients). In per-therapy analysis, the Hp eradication rate was 91% (113 of 124 patients), and the ulcer healing rate was 95% (118 of 124 patients). Side effects were observed in 39 of 119 patients (33%) and were generally mild. The four-drug regimen used in this study, when given to patients previously treated unsuccessfully with standard triple therapy or PPI dual therapy, was highly effective in eradicating Hp and healing DUs and had no major side effects. |
| | |
Authors:
|
M Tzivras; V Balatsos; S Souyioultzis; M Tsirantonaki; N Skandalis; A Archimandritis |
Related Documents
:
|
21566549 - Oral supplementation with a nutraceutical containing echinacea, methionine and antioxid... 21738529 - Nonsurgical outpatient therapies for the management of female stress urinary incontinen... 21941449 - Benefit of intravenous antibiotic therapy in patients referred for treatment of neurolo... 22069099 - Efficacy and safety of (90)y-dotatate therapy in neuroendocrine tumours. 12165029 - Impact of furazolidone-based quadruple therapy for eradication of helicobacter pylori a... 8079929 - Effect of eradication of helicobacter pylori on serum pepsinogen i, gastrin, and insuli... 9736399 - Evaluation of treatment with a pulsed electromagnetic field on wound healing, clinicopa... 1882909 - Maintenance therapy with sucralfate in duodenal ulcer: genuine prevention or accelerate... 8743519 - Nitrendipine and enalapril in the treatment of diabetic hypertensive patients with micr... |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Clinical therapeutics Volume: 19 ISSN: 0149-2918 ISO Abbreviation: Clin Ther Publication Date: 1997 Sep-Oct |
Date Detail:
|
Created Date: 1997-12-30 Completed Date: 1997-12-30 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7706726 Medline TA: Clin Ther Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 906-12 Citation Subset: IM |
Affiliation:
|
Department of Pathophysiology, National University of Athens School of Medicine, Laiko General Hospital, Greece. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Aged, 80 and over Amoxicillin / adverse effects, therapeutic use* Anti-Bacterial Agents / adverse effects, therapeutic use* Anti-Ulcer Agents / adverse effects, therapeutic use* Diarrhea / chemically induced Drug Therapy, Combination Duodenal Ulcer / drug therapy* Female Helicobacter Infections / drug therapy* Helicobacter pylori / drug effects* Humans Male Metronidazole / adverse effects, therapeutic use* Middle Aged Nausea / chemically induced Omeprazole / adverse effects, therapeutic use* Organometallic Compounds / adverse effects, therapeutic use* Recurrence |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Bacterial Agents; 0/Anti-Ulcer Agents; 0/Organometallic Compounds; 26787-78-0/Amoxicillin; 443-48-1/Metronidazole; 57644-54-9/bismuth tripotassium dicitrate; 73590-58-6/Omeprazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Managing side effects of interferon-beta in patients with relapsing-remitting multiple sclerosis.
Next Document: Comparison of hydroxychloroquine with zidovudine in asymptomatic patients infected with human immuno...