| High-energy phosphates, myocardial contractile function and material properties after short periods of oxygen deficiency. | |
| | |
MedLine Citation:
|
PMID: 2923609 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
To investigate myocardial performance and diastolic properties after repeated periods of oxygen deficiency auxotonic and isovolumic measurements were performed after three periods (4 min) of asphyxia in Wistar rats (n = 19). Additionally, the response of the peak isovolumic left ventricular pressure to postextrasystolic potentiation was measured. The hemodynamic results were compared to the levels of high-energy phosphates. Already after 15 min of recovery from asphyxia auxotonic measures of systolic function were completely normal compared to the control group (n = 19). Isovolumic measurements after 20 min of postasphyctic recovery, however, demonstrated a considerable reduction of the peak left ventricular pressure (226.5 +/- 7.5 mm Hg vs. 262.6 +/- 3.4 mm Hg in controls, mean +/- SEM (p less than 0.01) indicating persistence of decreased postischemic contractile performance. The relative effect of postextrasystolic potentiation was similar in both groups, but could not compensate for the reduced performance of the postasphyctic hearts: the absolute postextrasystolic peak isovolumic pressure of the postasphyctic hearts was lower than the value of the regular isovolumic peak pressure in the controls. Diastolic properties (pressure/volume and stress/strain relationships) of the postasphyctic myocardium remained unchanged. The total sum of the adenine-nucleotides decreased from 7.2 +/- 0.2 to 5.6 +/- 0.3 mumol/gww (p less than 0.01). ATP was reduced from 4.8 +/- 0.2 to 3.9 +/- 0.3 mumol/gww (p less than 0.01). Phosphocreatine was elevated to 7.0 +/- 0.6 mumol/gww, x +/- SEM (p less than 0.01). Our results demonstrated normal postasphyctic basal hemodynamics and material properties. Thus, the energy supply was sufficient to maintain steady state conditions - in spite of decreased overall adenine-nucleotide levels. Isovolumic measurements and postextrasystolic potentation tests, however, indicated that the contractile performance of the postischemic myocardium was still reduced. This functional limitation cannot be explained by altered material properties and is probably not causally related to the decreased overall ATP content. |
| | |
Authors:
|
H M Hoffmeister; R Storf; K U Thiedemann; L Seipel |
Related Documents
:
|
10645929 - Effects of intravenous and intracoronary adenosine 5'-triphosphate as compared with ade... 8922309 - Comparison of intravenous adenosine to intracoronary papaverine for calculation of pres... 9541509 - Diastolic dysfunction and altered energetics in the alphamhc403/+ mouse model of famili... 3383379 - Formation of s-adenosylhomocysteine in the heart. ii: a sensitive index for regional my... 9726619 - Effects of adenosine infusion with or without leukocyte depletion on recovery after hyp... 8763399 - Interstitial adenosine and cellular metabolism during beta-adrenergic stimulation of th... 9029899 - Changes of vasoactive peptides and effects of inhaled nitric oxide after pneumonectomy. 11603909 - The impact of high pressure vs low pressure stent implantation on intimal hyperplasia a... 10777029 - Transvascular albumin leakage and forearm vasodilatation to acetylcholine in essential ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Basic research in cardiology Volume: 84 ISSN: 0300-8428 ISO Abbreviation: Basic Res. Cardiol. Publication Date: 1989 Jan-Feb |
Date Detail:
|
Created Date: 1989-04-20 Completed Date: 1989-04-20 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0360342 Medline TA: Basic Res Cardiol Country: GERMANY, WEST |
Other Details:
|
Languages: eng Pagination: 77-90 Citation Subset: IM |
Affiliation:
|
Medizinische Klinik, University of Tübingen, FRG. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenine Nucleotides
/
metabolism* Adenosine Diphosphate / metabolism Adenosine Monophosphate / metabolism Adenosine Triphosphate / metabolism Animals Anoxia / metabolism, physiopathology* Cardiac Volume Heart / physiopathology Male Myocardial Contraction* Myocardium / metabolism Phosphocreatine / metabolism Pressure Rats Rats, Inbred Strains Stroke Volume |
| Chemical | |
Reg. No./Substance:
|
0/Adenine Nucleotides; 56-65-5/Adenosine Triphosphate; 58-64-0/Adenosine Diphosphate; 61-19-8/Adenosine Monophosphate; 67-07-2/Phosphocreatine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Enhanced myocardial preservation by nicotinic acid, an antilipolytic compound: mechanism of action.
Next Document: Individualizing the Good Behavior Game across type and frequency of behavior with emotionally distur...