Document Detail


High energy phosphate depletion and lactate accumulation in the interventricular septum and left ventricular free wall of the dog after total coronary occlusion.
MedLine Citation:
PMID:  6713606     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We measured indices of energy metabolism in tissue samples taken from the interventricular septum and left ventricular free wall of open-chest dogs under control conditions and after a 20-second period of no coronary inflow. The heart was paced at 150 beats/min, and arterial pressure was controlled by aortic constriction. Each tissue sample was divided into three transmural regions and analyzed for creatine phosphate, adenosine triphosphate, and lactate. Data were also obtained in animals subjected to ventricular fibrillation, with ventricular pressures reduced to atmosphere and sampling delayed to 70 seconds, and with the pulmonary artery constricted prior to coronary artery occlusion. In control animals, there were no metabolite differences between the free wall and septum. Coronary occlusion produced a lactate gradient across both the free wall and septum, with the highest lactate concentrations occurring in the regions adjacent to the left ventricular cavity. The increase in tissue lactate above control was greater in the septum than in the free wall. Coronary occlusion decreased tissue creatine phosphate but not adenosine triphosphate. The decrease in creatine phosphate was greater in the septum than in the free wall. Coronary occlusion and ventricular fibrillation, or coronary occlusion and ventricular pressures reduced to atmosphere, produced neither transmural metabolite differences nor differences between the free wall and septum. Pulmonary artery constriction increased right and decreased left ventricular pressures.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
R B Dunn
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation research     Volume:  54     ISSN:  0009-7330     ISO Abbreviation:  Circ. Res.     Publication Date:  1984 Apr 
Date Detail:
Created Date:  1984-06-01     Completed Date:  1984-06-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0047103     Medline TA:  Circ Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  405-13     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adenosine Triphosphate / metabolism
Animals
Arterial Occlusive Diseases / metabolism*,  physiopathology
Blood Pressure
Coronary Disease / metabolism*,  physiopathology
Dogs
Energy Metabolism
Heart Septum / metabolism*
Heart Ventricles / metabolism
Lactates / metabolism*
Male
Phosphates / metabolism*
Phosphocreatine / metabolism
Pulmonary Artery / physiopathology
Grant Support
ID/Acronym/Agency:
RR-05366/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Lactates; 0/Phosphates; 56-65-5/Adenosine Triphosphate; 67-07-2/Phosphocreatine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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