Document Detail

High end tidal CO2 association with blood pressure response to sodium loading in older adults.
MedLine Citation:
PMID:  8986906     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To test the hypothesis that blood pressure of older adults with high resting end tidal CO2 (PETCO2) is sensitive to high dietary intake of sodium chloride. DESIGN AND METHODS: Forty-four Caucasian men and women, aged 41-79 years (mean +/- SEM 55.5 +/- 1.4), restricted their dietary intake of sodium chloride for 11 days and ingested sodium chloride capsules (an additional 190 mmol sodium/day) during the last seven of those days. On days 1, 4 and 11, resting PETCO2 and blood pressure were monitored for 25 min in the laboratory, followed by ambulatory blood pressure monitoring in the natural environment for 24 h. Overnight urine samples were obtained at days 4 and 11 to estimate excretion of sodium and of an endogenous digitalis-like factor (EDLF) that is sensitive to changes in plasma volume. RESULTS: Individual resting PETCO2 remained stable within and between laboratory monitoring sessions and was correlated with urinary excretion of the endogenous digitalis-like factor, both before and after the period of high sodium intake. The high-sodium diet was associated with increased urinary sodium excretion and body weight in all quartiles of PETCO2. The high-sodium diet produced significant increases in resting and in 24 h systolic blood pressures in the upper two quartiles of the PETCO2 distribution, and significant increases in resting and in 24 h diastolic blood pressures in the highest PETCO2 quartile only. CONCLUSION: These findings indicate blood pressure sensitivity to sodium loading is differentially associated with high resting PETCO2 in older adults. A high PETCO2 may be an index of a dynamic steady state that influences sodium transport mechanisms.
D E Anderson; A Dhokalia; D J Parsons; A Y Bagrov
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of hypertension     Volume:  14     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1997-03-20     Completed Date:  1997-03-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1073-9     Citation Subset:  IM    
Laboratory of Behavioral Sciences, National Institute on Aging, Baltimore, Maryland, USA.
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MeSH Terms
Age Factors
Blood Pressure*
Body Weight
Carbon Dioxide / analysis*
Heart Rate
Middle Aged
Regression Analysis
Sodium, Dietary / administration & dosage*
Reg. No./Substance:
0/Sodium, Dietary; 124-38-9/Carbon Dioxide

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