Document Detail


High-efficiency Semliki Forest virus-mediated transduction in bovine adrenal chromaffin cells.
MedLine Citation:
PMID:  10477258     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adrenal chromaffin cells are commonly used in studies of exocytosis. Progress in characterizing the molecular mechanisms has been slow, because no simple, high-efficiency technique is available for introducing and expressing heterologous cDNA in chromaffin cells. Here we demonstrate that Semliki Forest virus (SFV) vectors allow high-efficiency expression of heterologous protein in chromaffin cells.
Authors:
R R Duncan; A C Don-Wauchope; S Tapechum; M J Shipston; R H Chow; P Estibeiro
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Biochemical journal     Volume:  342 Pt 3     ISSN:  0264-6021     ISO Abbreviation:  Biochem. J.     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-12-08     Completed Date:  1999-12-08     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  497-501     Citation Subset:  IM    
Affiliation:
Membrane Biology Group, Biomedical Sciences, University of Edinburgh Medical School, Teviot Place, Edinburgh, EH8 9XD, U.K.
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MeSH Terms
Descriptor/Qualifier:
Adrenal Medulla / cytology*
Animals
Cattle
Chromaffin Cells / cytology,  virology*
Culture Media
Electrophysiology
Exocytosis
Gene Transfer Techniques*
Green Fluorescent Proteins
Luminescent Proteins / genetics,  metabolism
Mice
Microscopy, Confocal
Polymerase Chain Reaction
Semliki forest virus / genetics*
Grant Support
ID/Acronym/Agency:
//Wellcome Trust
Chemical
Reg. No./Substance:
0/Culture Media; 0/Luminescent Proteins; 147336-22-9/Green Fluorescent Proteins
Comments/Corrections

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