Document Detail


High doses intravenous immunoglobulin versus oral cyclosporine in the treatment of severe atopic dermatitis.
MedLine Citation:
PMID:  17301437     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Atopic dermatitis is one of the most common allergic diseases that almost always respond to conventional therapies with topical emollient, topical corticosteroids, systemic antihistamines and allergic abstinence. However few cases of atopic dermatitis with severe course do not respond to conventional therapies and high dose of intravenous immunoglobulin or cyclosporine are recommended for them. This clinical trial study has been done to compare the last two regimens in patients with severe atopic dermatitis, Scoring Atopic Dermatitis (SCORAD) greater than 70. We included 14 patients in two groups. In group 1, eight patients were randomly selected and received 4mg/kg cyclosporine daily for 3 months and in group 2, six patients received 2g/kg Intravenous Immunoglobulin (IVIG) as stat infusion. All patients were followed on days 15, 30, 60 and 90 after starting the therapy. About 75% and 62.5% of patients had positive skin tests to egg and to milk respectively. Six patients out of 14 patients did not have skin test, so specific IgE by Radioallergosobent tests (RAST) was used for them. All of these patients had positive RAST to egg and 66.6% against cow's milk. There was a significant difference in the clinical outcomes of these two groups with a marked reduction in SCORAD of day 90th in group 1 in comparison to group 2 (P-value = 0.005). No significant adverse drug reaction was seen in these two groups.
Authors:
Mohammad Hassan Bemanian; Masoud Movahedi; Abolhassan Farhoudi; Mohammad Gharagozlou; Mehran Heidari Seraj; Zahra Pourpak; Mohammad Nabavi; Asghar Aghamohammadi; Zahra Shirkhoda
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Iranian journal of allergy, asthma, and immunology     Volume:  4     ISSN:  1735-1502     ISO Abbreviation:  Iran J Allergy Asthma Immunol     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2007-02-15     Completed Date:  2008-03-26     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  101146178     Medline TA:  Iran J Allergy Asthma Immunol     Country:  Iran    
Other Details:
Languages:  eng     Pagination:  139-43     Citation Subset:  -    
Affiliation:
Department of Immunology, Asthma and Allergy, Children's Hospital Medical Center, Tehran University of Medical Sciences, Tehran, Iran. mhbemanian@razi.tums.ac.ir.
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