Document Detail

High-dose tamoxifen in treatment of brain tumors: interaction with antiepileptic drugs.
MedLine Citation:
PMID:  7614929     Owner:  NLM     Status:  MEDLINE    
The incidence of seizures related to primary brain tumors is 20-80%. High-dose tamoxifen was recently reported as a novel treatment for patients with malignant gliomas who have failed standard therapies. Tamoxifen inhibits protein kinase C (PKC) in vitro and thus may regulate glioma cell growth by modulating intracellular signal transduction. We report a patient with a recurrent supratentorial pilocytic astrocytoma who had an untoward interaction between high-dose tamoxifen therapy and phenytoin (PHT), drugs that share a common enzyme for metabolism, therefore emphasizing the need to monitor concomitant antiepileptic drug (AED) levels when high-dose tamoxifen therapy is instituted.
A L Rabinowicz; D R Hinton; P Dyck; W T Couldwell
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Epilepsia     Volume:  36     ISSN:  0013-9580     ISO Abbreviation:  Epilepsia     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-08-22     Completed Date:  1995-08-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  513-5     Citation Subset:  IM    
USC Epilepsy Center, University of Southern California School of Medicine, Los Angeles, USA.
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MeSH Terms
Brain Neoplasms / drug therapy*,  enzymology
Cell Division / drug effects
Drug Interactions
Glioma / drug therapy*,  enzymology
Magnetic Resonance Imaging
Phenytoin / adverse effects,  pharmacology*
Protein Kinase C / antagonists & inhibitors
Signal Transduction / drug effects
Tamoxifen / pharmacology,  therapeutic use*
Reg. No./Substance:
10540-29-1/Tamoxifen; 57-41-0/Phenytoin; EC Kinase C

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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