Document Detail


High-dose steroids do not improve early outcome in biliary atresia.
MedLine Citation:
PMID:  18082717     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Our objective was to evaluate the effects of steroids on early outcome in biliary atresia (BA). METHODS: Patients with BA between 2001 and 2005 were reviewed. The use of steroids (4 mg/kg per day at alternate days for 1 to 3 months) has been routinely implemented since 2003. Jaundice-free status and the occurrence of cholangitis at 6 months postoperatively between patients receiving steroids and those not receiving steroids were compared. RESULTS: Fifty-three patients with BA were studied. At 6 months postoperation, 30 patients (56.6%) were jaundice free and 24 patients (45.3%) experienced cholangitis at least once. Of the 53 patients, there were 33 patients in the steroid group and 20 patients in the nonsteroid group. The proportion of jaundice-free patients in the steroid group was higher than that in the nonsteroid group, and the proportion of patients with cholangitis in the steroid group was lower than that in the nonsteroid group. However, these discrepancies did not reach a statistically significant difference (jaundice-free status [steroid vs nonsteroid]: 20/33 [60.6%] vs 10/20 [50%], P = .57; cholangitis: 13/33 [39.4%] vs 11/20 [55%], P = .39). CONCLUSIONS: Although the use of steroids seems to have benefits, it did not statistically improve early outcome in patients with BA.
Authors:
Paisarn Vejchapipat; Rojjana Passakonnirin; Paiboon Sookpotarom; Soottiporn Chittmittrapap; Yong Poovorawan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pediatric surgery     Volume:  42     ISSN:  1531-5037     ISO Abbreviation:  J. Pediatr. Surg.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-17     Completed Date:  2008-01-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0052631     Medline TA:  J Pediatr Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2102-5     Citation Subset:  IM    
Affiliation:
Department of Surgery, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand. pvejchap@yahoo.co.uk
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MeSH Terms
Descriptor/Qualifier:
Biliary Atresia / drug therapy*,  surgery*
Biliary Tract Surgical Procedures / methods
Case-Control Studies
Dose-Response Relationship, Drug
Drug Administration Schedule
Female
Follow-Up Studies
Humans
Infant
Infant, Newborn
Male
Postoperative Care
Prednisolone / administration & dosage*
Probability
Reference Values
Retrospective Studies
Risk Assessment
Severity of Illness Index
Time Factors
Treatment Outcome
Chemical
Reg. No./Substance:
50-24-8/Prednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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