| High-dose senna compared with conventional PEG-ES lavage as bowel preparation for elective colonoscopy: a prospective, randomized, investigator-blinded trial. | |
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MedLine Citation:
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PMID: 16393219 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare the efficacy and patient acceptance of an oral high dose of senna to conventional polyethylene glycol-electrolyte lavage solution (PEG-ES) in adults undergoing elective colonoscopy. METHODS: Consecutive outpatients referred for elective colonoscopy were prospectively randomly assigned to receive, the day before the procedure, either 24 tablets of 12 mg senna, divided into two doses at 1 p.m. and 9 p.m. (senna group, n=191), or standard 4-L PEG-ES (PEG-ES group, n=92). The overall quality of colon cleansing (primary outcome measure) and cleansing in the right colon were evaluated using the Aronchick scoring scale (1=excellent to 4=inadequate) by the investigator/endoscopist who was blinded to the treatment assignment. Patient acceptance and the safety of the preparation were assessed by a nurse, using a structured questionnaire covering compliance with the dosing, overall tolerance of the preparation (1=none or mild discomfort to 4=severely distressing), and adverse events. RESULTS: The quality of colon cleansing, overall tolerance of the preparation, and compliance were significantly better with senna; overall cleansing was excellent or good in 90.6% of patients in the senna group and in 79.7% in the PEG-ES group (p= 0.003). The percentage of procedures rescheduled because of insufficient colon cleansing was 7.3% in the PEG-ES group and 2.6% in the senna group (p=0.035). Multivariate logistic regression modeling showed the PEG-ES preparation as negative independent predictor of unsuccessful bowel cleansing. The incidence of adverse reactions was similar in the two groups; patients who received senna experienced significantly less nausea and vomiting, but more abdominal pain. CONCLUSIONS: An oral high dose of senna is a valid alternative to standard PEG-ES for outpatient colonoscopy preparation. |
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Authors:
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Franco Radaelli; Gianmichele Meucci; Gianni Imperiali; Giancarlo Spinzi; Enrico Strocchi; Vittorio Terruzzi; Giorgio Minoli |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: The American journal of gastroenterology Volume: 100 ISSN: 0002-9270 ISO Abbreviation: Am. J. Gastroenterol. Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2006-01-05 Completed Date: 2006-01-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0421030 Medline TA: Am J Gastroenterol Country: United States |
Other Details:
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Languages: eng Pagination: 2674-80 Citation Subset: IM |
Affiliation:
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Division of Gastroenterology, Valduce Hospital, Como, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Aged Ambulatory Care Cathartics / administration & dosage* Colonoscopy / methods* Dose-Response Relationship, Drug Female Humans Irrigation / methods Male Middle Aged Patient Satisfaction Polyethylene Glycols / administration & dosage* Prospective Studies Risk Assessment Senna Extract / administration & dosage*, adverse effects Sensitivity and Specificity Single-Blind Method Surgical Procedures, Elective |
| Chemical | |
Reg. No./Substance:
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0/Cathartics; 0/Polyethylene Glycols; 8013-11-4/Senna Extract |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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