| High-dose preoperative radiation and radical sphincter-preserving surgery for rectal cancer. | |
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MedLine Citation:
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PMID: 1842184 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To reduce local recurrence associated with rectal cancer and to extend the scope of anal sphincter preservation, a selective program of high-dose preoperative radiation therapy and sphincter-preserving surgery was initiated in 1976. High-energy photon therapy (40 to 60 Gy) was administered in doses of 1.8 to 2.5 Gy during a period of 4 1/2 to 6 weeks and followed in 4 to 6 weeks with curative sphincter-preserving surgery for clinicopathologically unfavorable and low rectal cancers. None of the 143 patients in the study died during the postoperative period. Fifteen (13%) of 117 patients followed up for at least 24 months experienced local recurrence. Acceptable sphincter function was retained in 130 patients (91%). Our program of high-dose preoperative radiation therapy and sphincter-preserving surgery for the treatment of high-risk cancers, including those in the distal third of the rectum, resulted in better-than-expected survival and control of local recurrence with acceptable morbidity and no mortality. |
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Authors:
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G Marks; M Mohiuddin; A Eitan; L Masoni; J Rakinic |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Archives of surgery (Chicago, Ill. : 1960) Volume: 126 ISSN: 0004-0010 ISO Abbreviation: Arch Surg Publication Date: 1991 Dec |
Date Detail:
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Created Date: 1992-12-03 Completed Date: 1992-12-03 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9716528 Medline TA: Arch Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1534-40 Citation Subset: AIM; IM |
Affiliation:
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Department of Surgery, Comprehensive Rectal Cancer Center, Thomas Jefferson University Hospital, Philadelphia, Pa. 19107-5098. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Combined Modality Therapy Follow-Up Studies Humans Neoplasm Recurrence, Local Postoperative Complications Preoperative Care Radiotherapy, High-Energy* Rectal Neoplasms / mortality, physiopathology, radiotherapy*, surgery* Survival Rate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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