Document Detail

High-dose preoperative radiation and radical sphincter-preserving surgery for rectal cancer.
MedLine Citation:
PMID:  1842184     Owner:  NLM     Status:  MEDLINE    
To reduce local recurrence associated with rectal cancer and to extend the scope of anal sphincter preservation, a selective program of high-dose preoperative radiation therapy and sphincter-preserving surgery was initiated in 1976. High-energy photon therapy (40 to 60 Gy) was administered in doses of 1.8 to 2.5 Gy during a period of 4 1/2 to 6 weeks and followed in 4 to 6 weeks with curative sphincter-preserving surgery for clinicopathologically unfavorable and low rectal cancers. None of the 143 patients in the study died during the postoperative period. Fifteen (13%) of 117 patients followed up for at least 24 months experienced local recurrence. Acceptable sphincter function was retained in 130 patients (91%). Our program of high-dose preoperative radiation therapy and sphincter-preserving surgery for the treatment of high-risk cancers, including those in the distal third of the rectum, resulted in better-than-expected survival and control of local recurrence with acceptable morbidity and no mortality.
G Marks; M Mohiuddin; A Eitan; L Masoni; J Rakinic
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Archives of surgery (Chicago, Ill. : 1960)     Volume:  126     ISSN:  0004-0010     ISO Abbreviation:  Arch Surg     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1992-12-03     Completed Date:  1992-12-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9716528     Medline TA:  Arch Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1534-40     Citation Subset:  AIM; IM    
Department of Surgery, Comprehensive Rectal Cancer Center, Thomas Jefferson University Hospital, Philadelphia, Pa. 19107-5098.
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MeSH Terms
Combined Modality Therapy
Follow-Up Studies
Neoplasm Recurrence, Local
Postoperative Complications
Preoperative Care
Radiotherapy, High-Energy*
Rectal Neoplasms / mortality,  physiopathology,  radiotherapy*,  surgery*
Survival Rate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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