Document Detail


High-dose penicillin therapy in meningopolyneuritis Garin-Bujadoux-Bannwarth. Clinical and cerebrospinal fluid data.
MedLine Citation:
PMID:  3591089     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Clinical data of 19 patients with meningopolyneuritis Garin-Bujadoux-Bannwarth (MPN-GBB), treated with 2 X 10 million units intravenous sodium penicillin for 10 days, were evaluated at the beginning of therapy, 3 weeks thereafter, and 6 months after onset of the neurological disease. Cerebrospinal fluid (CSF) was analysed in 14 patients at the onset of therapy and 3 1/2 weeks thereafter. At the same interval antibodies against B. burgdorferi were measured by enzyme-linked immunosorbent assay (ELISA) in the CSF and sera of 12 patients. Clinical data and all CSF results, with exception of specific antibody titers, were compared with those of patients who had suffered from MPN-GBB between 1979 and 1983, and who had not received antibiotic or corticosteroid therapy. Comparing the clinical data of all treated patients with those of all non-treated controls, no significant difference could be observed. A significant improvement could however be detected in those patients who had their treatment begun 5 weeks within onset of the neurological disease. Changes in CSF 3 1/2 weeks after onset of treatment showed slight differences when compared with controls.
Authors:
W Kristoferitsch; U Baumhackl; E Sluga; G Stanek; K Zeiler
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Zentralblatt für Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology     Volume:  263     ISSN:  0176-6724     ISO Abbreviation:  Zentralbl Bakteriol Mikrobiol Hyg A     Publication Date:  1987 Feb 
Date Detail:
Created Date:  1987-06-29     Completed Date:  1987-06-29     Revised Date:  2009-06-08    
Medline Journal Info:
Nlm Unique ID:  8403032     Medline TA:  Zentralbl Bakteriol Mikrobiol Hyg A     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  357-64     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Antibodies, Bacterial / cerebrospinal fluid
Borrelia / immunology
Borrelia Infections / cerebrospinal fluid,  drug therapy*
Child
Child, Preschool
Female
Humans
Male
Meningitis / cerebrospinal fluid,  drug therapy*
Middle Aged
Penicillins / therapeutic use*
Polyneuropathies / cerebrospinal fluid,  drug therapy*
Chemical
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Penicillins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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