Document Detail

High-dose midazolam and the attenuation of the contractile response to vasoconstrictors in coronary artery segments.
MedLine Citation:
PMID:  12703833     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVE: Benzodiazepines may cause hypotension and are reported to interfere with smooth vascular muscle activity. The aim was to elucidate the influence of three different benzodiazepines on the vascular reactivity of coronary arteries. METHODS: Using the model of isolated vessels, we studied the impact of midazolam (0.15, 1.5, 15 microg mL(-1)), diazepam (0.1, 1.0, 10 microg mL(-1)) and flunitrazepam (0.01, 0.1, 1.0 microg mL(-1)) on the contractile responses to histamine (2 x 10(-5) mol L(-1)) and serotonin (3 x 10(-5) mol L(-1)) in isolated intact and denuded coronary arteries. RESULTS: Midazolam significantly attenuated the contractile response when administered in high concentrations (15 microg mL(-1)). This effect was more pronounced in intact than in denuded preparations (histamine: -22.7 versus -7.3%, P = 0.0079; serotonin: -47.1 versus -15.9%, P < 0.0001). Diazepam and flunitrazepam exerted no significant effects on the vascular tone of coronary arteries. CONCLUSIONS: Midazolam, but not diazepam or flunitrazepam, attenuates the contractile responses to vasoconstrictors in concentrations beyond those used in clinical practice. This effect is in part mediated by endothelial factors.
A P Klockgether-Radke; A Thudium; A Frerichs; D Kettler; G Hellige
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  European journal of anaesthesiology     Volume:  20     ISSN:  0265-0215     ISO Abbreviation:  Eur J Anaesthesiol     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-04-21     Completed Date:  2003-07-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8411711     Medline TA:  Eur J Anaesthesiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  289-93     Citation Subset:  IM    
Georg-August University of Göttingen, Department of Anaesthesiological Research, Centre of Anaesthesiology, Emergency and Intensive Care Medicine, Göttingen, Germany.
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MeSH Terms
Anti-Anxiety Agents / pharmacology
Diazepam / pharmacology
Dose-Response Relationship, Drug
Endothelium, Vascular
Flunitrazepam / pharmacology
Histamine / pharmacology
Hypnotics and Sedatives / administration & dosage,  pharmacology*
Midazolam / administration & dosage,  pharmacology*
Muscle Contraction / drug effects
Muscle, Smooth, Vascular / drug effects*
Serotonin / pharmacology
Vasoconstrictor Agents / antagonists & inhibitors*,  pharmacology
Reg. No./Substance:
0/Anti-Anxiety Agents; 0/Hypnotics and Sedatives; 0/Vasoconstrictor Agents; 1622-62-4/Flunitrazepam; 439-14-5/Diazepam; 50-67-9/Serotonin; 51-45-6/Histamine; 59467-70-8/Midazolam

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