Document Detail

High-dose methylprednisolone in a pregnant woman with Crohn's disease and adrenal suppression in her newborn.
MedLine Citation:
PMID:  18784429     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The synthetic corticosteroid methylprednisolone is used for the treatment of acute exacerbations of Crohn's disease, also in pregnancy. Its use is considered to be less harmful than the effect of active disease on the fetus. Adrenal suppression in a fetus due to administration of methylprednisolone has hitherto been rarely published. OBJECTIVE: To present a case of neonatal adrenal suppression due to the use of high-dose methylprednisolone in late pregnancy of a woman with Crohn's disease. METHODS AND RESULTS: Clinical signs of adrenal suppression were observed in the newborn 3 h after birth. After hydrocortisone supplementation and intensive therapy the baby recovered completely. CONCLUSIONS: Life-threatening adrenal suppression, requiring hydrocortisone supplementation and intensive therapy, was observed and successfully treated in a newborn, whose mother had received high-dose methylprednisolone in late pregnancy.
Vesna Homar; Stefan Grosek; Tadej Battelino
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-09-11
Journal Detail:
Title:  Neonatology     Volume:  94     ISSN:  1661-7819     ISO Abbreviation:  -     Publication Date:  2008  
Date Detail:
Created Date:  2008-11-10     Completed Date:  2009-01-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101286577     Medline TA:  Neonatology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  306-9     Citation Subset:  IM    
Copyright Information:
Copyright 2008 S. Karger AG, Basel.
Department of Pediatric Surgery and Intensive Therapy, University Medical Center Ljubljana, Ljubljana, Slovenia.
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MeSH Terms
Adrenal Insufficiency / chemically induced*,  drug therapy
Crohn Disease / drug therapy*
Dose-Response Relationship, Drug
Hydrocortisone / therapeutic use*
Infant, Newborn
Methylprednisolone / administration & dosage,  adverse effects*
Pregnancy Complications / drug therapy*
Prenatal Exposure Delayed Effects / chemically induced*
Reg. No./Substance:
50-23-7/Hydrocortisone; 83-43-2/Methylprednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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