| High-dose methylprednisolone in a pregnant woman with Crohn's disease and adrenal suppression in her newborn. | |
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MedLine Citation:
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PMID: 18784429 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The synthetic corticosteroid methylprednisolone is used for the treatment of acute exacerbations of Crohn's disease, also in pregnancy. Its use is considered to be less harmful than the effect of active disease on the fetus. Adrenal suppression in a fetus due to administration of methylprednisolone has hitherto been rarely published. OBJECTIVE: To present a case of neonatal adrenal suppression due to the use of high-dose methylprednisolone in late pregnancy of a woman with Crohn's disease. METHODS AND RESULTS: Clinical signs of adrenal suppression were observed in the newborn 3 h after birth. After hydrocortisone supplementation and intensive therapy the baby recovered completely. CONCLUSIONS: Life-threatening adrenal suppression, requiring hydrocortisone supplementation and intensive therapy, was observed and successfully treated in a newborn, whose mother had received high-dose methylprednisolone in late pregnancy. |
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Authors:
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Vesna Homar; Stefan Grosek; Tadej Battelino |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-09-11 |
Journal Detail:
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Title: Neonatology Volume: 94 ISSN: 1661-7819 ISO Abbreviation: - Publication Date: 2008 |
Date Detail:
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Created Date: 2008-11-10 Completed Date: 2009-01-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101286577 Medline TA: Neonatology Country: Switzerland |
Other Details:
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Languages: eng Pagination: 306-9 Citation Subset: IM |
Copyright Information:
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Copyright 2008 S. Karger AG, Basel. |
Affiliation:
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Department of Pediatric Surgery and Intensive Therapy, University Medical Center Ljubljana, Ljubljana, Slovenia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Insufficiency
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chemically induced*,
drug therapy Adult Crohn Disease / drug therapy* Dose-Response Relationship, Drug Female Humans Hydrocortisone / therapeutic use* Infant, Newborn Male Methylprednisolone / administration & dosage, adverse effects* Pregnancy Pregnancy Complications / drug therapy* Prenatal Exposure Delayed Effects / chemically induced* |
| Chemical | |
Reg. No./Substance:
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50-23-7/Hydrocortisone; 83-43-2/Methylprednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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