| High-dose methotrexate during pregnancy: risk of malformations. | |
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MedLine Citation:
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PMID: 21180376 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Methotrexate is a cytotoxic and immunosuppressant drug mainly used in oncology and rheumatology. It is sometimes used at high doses to treat unruptured ectopic pregnancy. Methotrexate is teratogenic. Malformations reported after exposure in utero include: abnormalities of the skull and face, limb defects, failure of ossification, and congenital cardiopathy.The risk of malformations is probably dose-dependent and seems to be relatively low at the low weekly doses used in rheumatology. Three cases of malformations have been reported after failure of high-dose methotrexate in pregnancies that were misdiagnosed as ectopic. Two newborns had scoliosis, facial dysmorphism, limb malformations, or cardiopathy.The third newborn had minor malformations. In practice, high-dose methotrexate must only be used to treat ectopic pregnancy if the diagnosis has been confirmed. The woman should be informed of the risks to her unborn child in case of diagnostic error or treatment failure. |
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Authors:
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Prescrire international Volume: 19 ISSN: 1167-7422 ISO Abbreviation: Prescrire Int Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-12-24 Completed Date: 2011-01-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9439295 Medline TA: Prescrire Int Country: France |
Other Details:
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Languages: eng Pagination: 212-3 Citation Subset: T |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Drug-Induced
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etiology* Female Folic Acid Antagonists / adverse effects* Humans Methotrexate / adverse effects* Pregnancy Pregnancy, Ectopic / drug therapy* Risk Treatment Failure |
| Chemical | |
Reg. No./Substance:
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0/Folic Acid Antagonists; 59-05-2/Methotrexate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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