Document Detail

High-dose megestrol acetate. A possible treatment for cachexia.
MedLine Citation:
PMID:  3806918     Owner:  NLM     Status:  MEDLINE    
Weight loss and anorexia are significant complications of a variety of disorders and add morbidity to the underlying process. We observed marked weight gain (median, 5.1 kg; range, 0.9 to 20.1 kg) and appetite enhancement in 27 of the 28 patients with breast cancer receiving treatment consisting of high doses of oral megestrol acetate (480 to 1600 mg/d). Weight gain occurred regardless of pretreatment weight, extent of metastases, or response to therapy. Our results suggest a possible role for megestrol acetate in reversing anorexia and weight loss, thereby improving the quality of life of patients with cachexia. Further research is needed to establish the mechanism of weight gain and potential clinical applications.
N S Tchekmedyian; N Tait; M Moody; J Aisner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  JAMA     Volume:  257     ISSN:  0098-7484     ISO Abbreviation:  JAMA     Publication Date:  1987 Mar 
Date Detail:
Created Date:  1987-03-26     Completed Date:  1987-03-26     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  7501160     Medline TA:  JAMA     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1195-8     Citation Subset:  AIM; IM    
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MeSH Terms
Body Weight / drug effects
Breast Neoplasms / complications,  drug therapy
Cachexia / drug therapy*,  etiology
Megestrol / administration & dosage,  analogs & derivatives*,  therapeutic use
Megestrol Acetate
Middle Aged
Reg. No./Substance:
EA6LD1M70M/Megestrol; TJ2M0FR8ES/Megestrol Acetate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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