Document Detail

High-dose intravenous thrombolytic therapy in acute myocardial infarction: efficiency, tolerance, complications and influence on left ventricular performance.
MedLine Citation:
PMID:  3873155     Owner:  NLM     Status:  MEDLINE    
Ten patients with acute myocardial infarction (AMI) underwent coronarographic studies before, immediately after and ten days after an intravenous infusion of 1 500 000 I.U. streptokinase (STK). Mean time between onset of symptoms to initiation of STK infusion was 03 hours 34 minutes. Occlusion of the infarct-related vessel was present in all of them and successful thrombolysis was obtained in 8 of the patients. Systemic fibrinolytic activity was present in 9 patients, one of whom required a transfusion of blood because of severe bleeding. At ventriculography, the global left ventricular ejection fraction and the regional ventricular ejection fraction, whatever the area involved, showed no significant improvement 10 days after the procedure. This suggests that high-dose intravenous STK in AMI, although causing an effective thrombolysis, does not seem to improve early myocardial function.
M de Marneffe; E Van Thiel; M Ewalenko; P Mols; N Naeije; R Bernard; M Englert
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta cardiologica     Volume:  40     ISSN:  0001-5385     ISO Abbreviation:  Acta Cardiol     Publication Date:  1985  
Date Detail:
Created Date:  1985-06-12     Completed Date:  1985-06-12     Revised Date:  2009-06-11    
Medline Journal Info:
Nlm Unique ID:  0370570     Medline TA:  Acta Cardiol     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  183-98     Citation Subset:  IM    
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MeSH Terms
Cardiac Output / drug effects
Coronary Circulation / drug effects
Dose-Response Relationship, Drug
Heart Ventricles / drug effects
Infusions, Parenteral
Middle Aged
Myocardial Contraction / drug effects
Myocardial Infarction / drug therapy*
Streptokinase / administration & dosage,  therapeutic use*
Reg. No./Substance:
EC 3.4.-/Streptokinase

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