Document Detail


High-dose intravenous thrombolytic therapy in acute myocardial infarction: efficiency, tolerance, complications and influence on left ventricular performance.
MedLine Citation:
PMID:  3873155     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ten patients with acute myocardial infarction (AMI) underwent coronarographic studies before, immediately after and ten days after an intravenous infusion of 1 500 000 I.U. streptokinase (STK). Mean time between onset of symptoms to initiation of STK infusion was 03 hours 34 minutes. Occlusion of the infarct-related vessel was present in all of them and successful thrombolysis was obtained in 8 of the patients. Systemic fibrinolytic activity was present in 9 patients, one of whom required a transfusion of blood because of severe bleeding. At ventriculography, the global left ventricular ejection fraction and the regional ventricular ejection fraction, whatever the area involved, showed no significant improvement 10 days after the procedure. This suggests that high-dose intravenous STK in AMI, although causing an effective thrombolysis, does not seem to improve early myocardial function.
Authors:
M de Marneffe; E Van Thiel; M Ewalenko; P Mols; N Naeije; R Bernard; M Englert
Related Documents :
2850185 - Recovery of left ventricular function after myocardial infarction can be predicted imme...
20598975 - Left ventricular function in acute myocardial infarction treated with thrombolysis foll...
12651035 - Thrombolysis in myocardial infarction myocardial perfusion grade in angiography correla...
1806765 - Thrombolytic therapy: enhancement by platelet and platelet-derived mediator antagonists.
20331695 - Assessment of myocardial perfusion during adenosine stress using real time three-dimens...
2960725 - Right ventricular hypertrophy is an important determinant of right ventricular infarcti...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta cardiologica     Volume:  40     ISSN:  0001-5385     ISO Abbreviation:  Acta Cardiol     Publication Date:  1985  
Date Detail:
Created Date:  1985-06-12     Completed Date:  1985-06-12     Revised Date:  2009-06-11    
Medline Journal Info:
Nlm Unique ID:  0370570     Medline TA:  Acta Cardiol     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  183-98     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Cardiac Output / drug effects
Coronary Circulation / drug effects
Dose-Response Relationship, Drug
Heart Ventricles / drug effects
Humans
Infusions, Parenteral
Middle Aged
Myocardial Contraction / drug effects
Myocardial Infarction / drug therapy*
Streptokinase / administration & dosage,  therapeutic use*
Chemical
Reg. No./Substance:
EC 3.4.-/Streptokinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Comparative analysis of the use of levamisole and pyrogenal in the treatment of multiple sclerosis
Next Document:  Hemodynamic effects of nifedipine on secondary pulmonary hypertension in man.