| High-dose intravenous thrombolytic therapy in acute myocardial infarction: efficiency, tolerance, complications and influence on left ventricular performance. | |
MedLine Citation:
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PMID: 3873155 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ten patients with acute myocardial infarction (AMI) underwent coronarographic studies before, immediately after and ten days after an intravenous infusion of 1 500 000 I.U. streptokinase (STK). Mean time between onset of symptoms to initiation of STK infusion was 03 hours 34 minutes. Occlusion of the infarct-related vessel was present in all of them and successful thrombolysis was obtained in 8 of the patients. Systemic fibrinolytic activity was present in 9 patients, one of whom required a transfusion of blood because of severe bleeding. At ventriculography, the global left ventricular ejection fraction and the regional ventricular ejection fraction, whatever the area involved, showed no significant improvement 10 days after the procedure. This suggests that high-dose intravenous STK in AMI, although causing an effective thrombolysis, does not seem to improve early myocardial function. |
Authors:
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M de Marneffe; E Van Thiel; M Ewalenko; P Mols; N Naeije; R Bernard; M Englert |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta cardiologica Volume: 40 ISSN: 0001-5385 ISO Abbreviation: Acta Cardiol Publication Date: 1985 |
Date Detail:
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Created Date: 1985-06-12 Completed Date: 1985-06-12 Revised Date: 2009-06-11 |
Medline Journal Info:
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Nlm Unique ID: 0370570 Medline TA: Acta Cardiol Country: BELGIUM |
Other Details:
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Languages: eng Pagination: 183-98 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cardiac Output / drug effects Coronary Circulation / drug effects Dose-Response Relationship, Drug Heart Ventricles / drug effects Humans Infusions, Parenteral Middle Aged Myocardial Contraction / drug effects Myocardial Infarction / drug therapy* Streptokinase / administration & dosage, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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EC 3.4.-/Streptokinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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